Why might the compound shown below act as a transition state analog of phosphoglucose isomerase? A drawing of the normal transition state for this enzyme is needed.
Why might the compound shown below act as a transition state analog of phosphoglucose isomerase? A drawing of the normal transition state for this enzyme is needed.
Phosphoglucose isomerase (PGI) is an enzyme belongs to class of isomerase enzyme which catalyzes the 2nd step of glycolysis i.e. reversible isomerization of D-glucose 6-phosphate to D-fructose 6-phosphate. The mechanism of this isomerism reaction occurs by acid-base catalysis via proton transfer. During this mechanism, formation of cis-enediol(ate) intermediate happens. It is present in the cytoplasm of cell and involves in both glycolysis and gluconeogenesis.
A transition state analog is the intermediate structure formed during the catalysis with equal probability of forming a product or substrate. It is a chemically stable molecule structure that is formed for the femto second timescale.
The given compound is "5-phosphoarabinonhydroxamic acid".
Step by step
Solved in 2 steps with 2 images
