Does the CRISPR-based gene therapy strategy for treating sickle cell anemia that was discussed conform to WHO guidelines for human genome editing issued in 2019 (https://www.who.int/news/item/26-07-2019-statement-on-governance-and-oversight-of-human-genome-editingLinks to an external site.)? Answer in 2-3 sentences that include information about what those guidelines say. Use the terms “somatic” and “germline” in your answer in a way that illustrates your understanding of the meaning of these terms when applied to gene therapy.
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
part 2 question 6
Does the CRISPR-based gene therapy strategy for treating sickle cell anemia that was discussed conform to WHO guidelines for human genome editing issued in 2019 (https://www.who.int/news/item/26-07-2019-statement-on-governance-and-oversight-of-human-genome-editingLinks to an external site.)? Answer in 2-3 sentences that include information about what those guidelines say. Use the terms “somatic” and “germline” in your answer in a way that illustrates your understanding of the meaning of these terms when applied to gene therapy.
The World Health Organisation (WHO) recommendations, which were released in 2019, provide a clear differentiation between somatic and germline genome editing. The field of somatic genome editing primarily concerns the targeted manipulation of the DNA inside certain cells or tissues of an organism. In contrast, germline genome editing pertains to the introduction of heritable alterations to an individual's genetic material, which may then be inherited by subsequent generations.
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