Academy of Sciences https://doi- org.ezproxy.library.yorku.ca/10.1073/pnas.231743012) has demonstrated that a 25 basepair deletion in the Bace2 gene causes brown and white coat colours in giant pandas. The authors used whole genome sequencing of 35 giant pandas, including 2 which are brown, and their families. They also knocked out the function of Bace2 in mice using CRISPR-Cas9. You do not need to look at this paper to answer the following questions. Brown panda bears do not have brown panda bear parents. From this, we know [more than one can be correctl

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A recent paper (Guan et al. 2024 Proceedings of the National
Academy of Sciences https://doi-
org.ezproxy.library.yorku.ca/10.1073/pnas.231743012)
has
demonstrated that a 25 basepair deletion in the Bace2 gene causes
brown and white coat colours in giant pandas. The authors used
whole genome sequencing of 35 giant pandas, including 2 which
are brown, and their families. They also knocked out the function of
Bace2 in mice using CRISPR-Cas9. You do not need to look at this
paper to answer the following questions.
Brown panda bears do not have brown panda bear parents. From
this, we know [more than one can be correct]
0000
the wild type allele at Bace2 is haplosufficent
Brown panda bears are infertile
the brown allele at Bace2 is recessive
That 25 basepair deletion has transposed elsewhere in the
genome
Է
No. of melanosomes per field of view
90
40
30
20
8 ཆེ ཥཾ  ྃ  ྴ སྐྱེ à ྜ
80
70
60
50
은 100
Black
*
Brown
Based on this figure, what is the predicted number of melanosomes
per field of view for a heterozygote for Base2?
0000
16
31
25
no way to know
Transcribed Image Text:A recent paper (Guan et al. 2024 Proceedings of the National Academy of Sciences https://doi- org.ezproxy.library.yorku.ca/10.1073/pnas.231743012) has demonstrated that a 25 basepair deletion in the Bace2 gene causes brown and white coat colours in giant pandas. The authors used whole genome sequencing of 35 giant pandas, including 2 which are brown, and their families. They also knocked out the function of Bace2 in mice using CRISPR-Cas9. You do not need to look at this paper to answer the following questions. Brown panda bears do not have brown panda bear parents. From this, we know [more than one can be correct] 0000 the wild type allele at Bace2 is haplosufficent Brown panda bears are infertile the brown allele at Bace2 is recessive That 25 basepair deletion has transposed elsewhere in the genome Է No. of melanosomes per field of view 90 40 30 20 8 ཆེ ཥཾ ྃ ྴ སྐྱེ à ྜ 80 70 60 50 은 100 Black * Brown Based on this figure, what is the predicted number of melanosomes per field of view for a heterozygote for Base2? 0000 16 31 25 no way to know
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