Consider the mRNA sequence below. Assume that the following mRNA segment has been translated. 5'-UACCGAAUGUCU-3' Note for numbers 1 and 2: Use the three-letter abbreviation of amino acid; separate amino acids with a hyphen: do not include the stop codon. Example: ala-cys-glu 1. Using the table of the genetic code, determine the sequence of amino acids. 2. If mutation occurs by substitution of the 12th nucleotide with cytidine-5'-monophosphate, what is the resulting amino acid sequence? 3. What type of mutation occurred? Choose from same sense, missense and non-sense.
Consider the mRNA sequence below. Assume that the following mRNA segment has been translated. 5'-UACCGAAUGUCU-3' Note for numbers 1 and 2: Use the three-letter abbreviation of amino acid; separate amino acids with a hyphen: do not include the stop codon. Example: ala-cys-glu 1. Using the table of the genetic code, determine the sequence of amino acids. 2. If mutation occurs by substitution of the 12th nucleotide with cytidine-5'-monophosphate, what is the resulting amino acid sequence? 3. What type of mutation occurred? Choose from same sense, missense and non-sense.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Consider the mRNA sequence below. Assume that the following mRNA segment has been
translated.
5'-UACCGAAUGUCU-3'
Note for numbers 1 and 2: Use the three-letter abbreviation of amino acid; separate amino acids
with a hyphen: do not include the stop codon.
Example: ala-cys-glu
1. Using the table of the genetic code, determine the sequence of amino acids.
2. If mutation occurs by substitution of the 12th nucleotide with cytidine-5'- monophosphate,
what is the resulting amino acid sequence?
3. What type of mutation occurred? Choose from same sense, missense and non-sense.
Transcribed Image Text:first base
A
U
UUU
phe
UUC
UUA
leu
UUG
CUU
leu
CUC
CUA
CUG
AUU
AUC ile
AUA
AUG met (start)
GUU
GUC
val
GUA
GUG
UCU
UCC
UCA
UCG
CCU
CCC
CCA
CCG
ACU
ACC
ADA
ACG
GCU
GCC
GCA
GCG
C
second base
A
UAU
UAC tyr
UAA Stop
UAG Stop
CAU
}
his
CAC
CAA
CAG
gin
AAU
asn
AAC
AAA
AAG
lys
GAU
asp
GAC
GAA
GAG glu
ser
pro
thr
ala
G
UGU
cys
UGC
UGA Stop
UGG trp
CGU
CGC
CGA
arg
CGG
AGU
ser
AGC
AGA
AGG
arg
GGU
GGO
gly
GGA
GGG
DUAGUCA DOAGUCAG
third base
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