Consider the effect of the hormone glucagon in the liver. Do you expect its effect on the following pathways would be to increase the rate (up-regulate) or decrease it (down-regulate) the rate? Use an arrow ↑ if the rate increases, or arrow if the rate decreases. By using an arrow upward or downward, how would it affect the concentration of glucose in the blood? Glycolysis Gluconeogenesis Glycogen degradation Glycogen synthesis Effect on blood glucose levels Glucagon
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- Under which of the following conditions would you NOT expect gluconeogenesis to occur? in response to cortisol in response to glucagon when ATP levels are low when glucose levels are low when fructose 1,6-bisphosphatase is activatedThe binding of insulin to its receptor on the surface of atarget cell activates the receptor’s tyrosine kinase activity,which in turn causes several phosphorylation cascades thatalter the activity of numerous enzymes and alters the expression of genes. Describe how one of these phosphorylationcascades stimulates glycogen synthesis.From this discussion of the hormonal regulation of glycogen metabolism. Read this material and summarize in no more than one page. Use figures and frame your narrative in terms of the picture. No resources other than the text are required or desirable.
- What is caused (indirectly) by the binding of a glucagon molecule to its receptor on the surface of a liver cell? Phosphorylation of glycogen phosphatase, which results in it becoming less active. Dephosphorylation of glycogen synthase, which results in it becoming less active Phosphorylation of glycogen phosphorylase, which results in it becoming more active Dephosphorylation of phosphorylase kinase, which results in it becoming more active. Phosphorylation of glycogen synthase, which results in it becoming more activeDifferent control mechanisms are used to regulate the synthesis of glycogen. Match the action on the left with the effect on the right. Increase in the concentration of inorganic phosphate ion Decrease in the activity of phosphoprotein phosphatase Phosphorylation of glycogen phosphorylase Dephosphorylation of glycogen synthase Ű Clear All Decreasing glycogen synthesis Increasing glycogen synthesis No effect on glycogen synthesisConsider regulation of glycolysis vs gluconeogenesis in the liver. Which of the following are more likely to promote the activity of gluconeogenesis rather than glycolysis? (select all that apply) Group of answer choices An increase in the ATP/AMP ratio A decrease/lack of F-2,6-BP The cell is in a low energy state Insulin signaling Glucagon signaling An abundance of citric acid cycle intermediates (i.e. citrate) Intense exercise Inhibition of pyruvate carboxylase Fasting
- In the regulation of glycogen phosphorylase, which of the following statements is true? The inactive T form becomes activated when it gets dephosphorylated. The active R form is inhibited by glucose. Phosphoprotein phosphatase catalyzes the attachment of a phosphate group to a Ser residue in glycogen phosphorylase. The allosteric modulator glucose-6-phosphate promotes the conformation change from inactive T state to active R state.Why does it make metabolic sense for the same hormone signal to stimulate glycogenolysis and inhibit glycolysis in the liver while stimulating both glycogenolysis and glycolysis in muscles?At normal to low blood glucose concentrations (1.e., roughly 110 mg/dl or less), the enzyme that is responsible for sequestering or trapping glucose within cells is which of the following enzymes? O hexokinase O glycogen synthase O glucose-6-phosphatase O glucokinase
- Which of the following biochemical reactions should be classified as endergonic (endothermic)? conversion of glucose into amylopectin conversion of lactose into glucose and galactose conversion of glycogen into glucose conversion of sucrose into glucose and fructose conversion of amylose into glucoseWhich of the following cellular concentrations would be likely to increase the rate of glycolysis? Low AMP levels High glucagon levels ✓Low fructose-2,6-bisphosphate levels High AMP levels High phosphoenolpyruvate levels Low ATP levelsT F T F T F T F T F T F T F Vmax is the velocity observed when all of the enzyme present is fully saturated with substrate; in other words, when [ES] = [E]total. High blood glucose levels are detected by insulin secreting cells of the pancreas initiating a positive feedback loop where insulin secreting cells of the pancreas stimulate the release of insulin into the blood lowering blood glucose levels. Steroids are hormones synthesized from cholesterol. Blood flow in the cardiovascular system is a diffusive process. Paracrine signaling involves exocytosis, diffusion over long distances, and systemic endocytosis in another tissue. At equilibrium d[A]/dt = d[B]/dt = 0 Steroid hormones can bind transcription factors on DNA enhancing transcription.