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Activity 4: Principles of Pharmacokinetics with Plasma Concentration Analysis Objective: To understand the impact of various routes of administration on the pharmacokinetics of drugs, specifically focusing on the absorption and bioavailability as influenced by the first pass effect. Instructions: 1. A table with plasma concentrations of Morphine at various time intervals is provided 2. Carefully review the data presented in the table, noting the time points and corresponding plasma concentrations. Plasma Concentrations for Morphine: Time After Dose (hours) IV Concentration Oral Solution (ng/mL) (ng/mL) Tablet (ng/mL) Capsule (ng/mL) IM (ng/mL) 2000 0 0 0 0 o 1 1500 200 150 120 800 2 1100 400 300 240 700 3 800 300 250 200 600 4 600 250 200 160 500 5 400 200 150 130 400

Activity 4: Principles of Pharmacokinetics with Plasma Concentration Analysis Objective: To understand the impact of various routes of administration on the pharmacokinetics of drugs, specifically focusing on the absorption and bioavailability as influenced by the first pass effect. Instructions: 1. A table with plasma concentrations of Morphine at various time intervals is provided 2. Carefully review the data presented in the table, noting the time points and corresponding plasma concentrations. Plasma Concentrations for Morphine: Time After Dose (hours) IV Concentration Oral Solution (ng/mL) (ng/mL) Tablet (ng/mL) Capsule (ng/mL) IM (ng/mL) 2000 0 0 0 0 o 1 1500 200 150 120 800 2 1100 400 300 240 700 3 800 300 250 200 600 4 600 250 200 160 500 5 400 200 150 130 400

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Activity 4: Principles of Pharmacokinetics with Plasma Concentration Analysis Objective: To understand the impact of various routes of administration on the pharmacokinetics of drugs, specifically focusing on the absorption and bioavailability as influenced by the first pass effect. Instructions: 1. A table with plasma concentrations of Morphine at various time intervals is provided 2. Carefully review the data presented in the table, noting the time points and corresponding plasma concentrations. Plasma Concentrations for Morphine: Time After Dose (hours) IV Concentration Oral Solution (ng/mL) (ng/mL) Tablet (ng/mL) Capsule (ng/mL) IM (ng/mL) 2000 0 0 0 0 o 1 1500 200 150 120 800 2 1100 400 300 240 700 3 800 300 250 200 600 4 600 250 200 160 500 5 400 200 150 130 400
Transcribed Image Text:Activity 4: Principles of Pharmacokinetics with Plasma Concentration Analysis Objective: To understand the impact of various routes of administration on the pharmacokinetics of drugs, specifically focusing on the absorption and bioavailability as influenced by the first pass effect. Instructions: 1. A table with plasma concentrations of Morphine at various time intervals is provided 2. Carefully review the data presented in the table, noting the time points and corresponding plasma concentrations. Plasma Concentrations for Morphine: Time After Dose (hours) IV Concentration Oral Solution (ng/mL) (ng/mL) Tablet (ng/mL) Capsule (ng/mL) IM (ng/mL) 2000 0 0 0 0 o 1 1500 200 150 120 800 2 1100 400 300 240 700 3 800 300 250 200 600 4 600 250 200 160 500 5 400 200 150 130 400
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