Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 25, Problem 20P
Consider the synthesis and degradation of tyrosine as shown in Figures 25.37, 25.38, and 25.48 to determine where the carbon atoms in PEP and erythrose-4-P would end up in acetoacetate and fumarate.
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Chapter 25 Solutions
Biochemistry
Ch. 25 - Prob. 1PCh. 25 - Prob. 2PCh. 25 - Regulation of Glutamine Synthetase by Covalent...Ch. 25 - The Energetic Cost of Nitrogen Excretion via the...Ch. 25 - Prob. 5PCh. 25 - Prob. 6PCh. 25 - Prob. 7PCh. 25 - Prob. 8PCh. 25 - Prob. 9PCh. 25 - Prob. 10P
Ch. 25 - Prob. 11PCh. 25 - Prob. 12PCh. 25 - Prob. 13PCh. 25 - Prob. 14PCh. 25 - Prob. 15PCh. 25 - A Deficiency on 3-Phosphogtycerate Dehydrogenase...Ch. 25 - Prob. 17PCh. 25 - Prob. 18PCh. 25 - Prob. 19PCh. 25 - Consider the synthesis and degradation of tyrosine...Ch. 25 - Prob. 21PCh. 25 - Prob. 22P
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- Name three enzymes that are likely the source of bicarbonate ion that is involved with the formation of carbamoyl phosphate? In the Ubiquitin pathway, why are there many more E3 proteins than E1 and E2 combined?arrow_forwardThe enzyme Glucose-6-phosphate dehydrogenase catalyzes the nicotinamide adenine dinucleotide oxidation of cyclic glucose-6-phosphate to form the lactone product shown below. Propose a mechanism for this reaction showing all electron flow (using the arrow convention). You must draw the substrate glucose-6-phosphate (the configuration of the anomeric carbon does not matter) and the “business end” of the cofactor.arrow_forwardWhat would be the metabolic consequences and symptoms of having a mutated form of phosphofructokinase-1 in muscle that is no longer allosterically regulated by [H+]? Speculate on how a patient with this mutation could deal with this.arrow_forward
- [1-14C]Ribose 5-phosphate is incubated with a mixture of purified transketolase, transaldolase, phosphopentose isomerase, phosphopentose epimerase, and glyceraldehyde 3-phosphate. Predict the distribution of radioactivity in the erythrose 4-phosphate and fructose 6-phosphate that were formed in this system. Diagram the reactions involved, showing the structures of each intermediate compound in the system and clearly indicating the location of the 14C in each molecule.arrow_forwardGive the name of two Molecules of Farnesyl Pyrophosphate:arrow_forwardThe hexapeptide Ala-Met-Leu-Lys-Phe-Asp is digested in the same tube with both Cyanogen Bromide and Trypsin at the same time at pH=7. Draw the structure of the product(s) that would bind to a cation exchange column. (Relevant pKa values are 2.2, 3.9, 9.5 and 10.5. Assume pKa values for any newly generated a-amino and a-carboxyl groups are 9.5 and 2.2 respectively)arrow_forward
- Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose‑6‑phosphate. Give two reasons why a Mg2+ cation is required to facilitate this reaction.arrow_forwardA mutated IDH1 isoenzyme is found in a high percentage of a type of brain cancer called glioblastoma. Instead of converting isocitrate to α-ketoglutarate, mutated IDH1 converts its substrate to 2-hydroxyglutarate, a circumstance that disrupts the citric acid cycle, among other effects. Review the structures of isocitrate and α-ketoglutarate and determine the structure of 2- hydroxyglutaratearrow_forwardConsider a series of experiments in which 32P-labeled inorganic phosphate were introduced to erythrocytes (red blood cells) undergoing glycolysis. Would you expect to see the labeled phosphate in any glycolytic intermediates? If so, which and at what relative concentrations?arrow_forward
- Sphingosine 1-phosphate (SPP) is important for cell survival. The synthesis of SPP from sphingosine and ATP is catalyzed by the enzyme sphingosine kinase. An understanding of the kinetics of the sphingosine kinase reaction may be important in the development of drugs to treat cancer. The velocity of the sphingosine kinase reaction was measured in the presence and absence of threo-sphingosine, a stereoisomer of sphingosine that inhibits the enzyme. The results are shown below .[Sphingosine], μM 2.5 3.5 5 10 20 50 v0(mg·minꟷ1) no inhibitor 32.3 40 50.872 87.7 115.4 v0(mg·minꟷ1)with threo-sphingosine 8.5 11.5 14.6 25.4 43.9 70.8 Construct a Lineweaver-Burk plot to answer the following questions:(A)What are the apparent KMand Vmaxvalues in the presence and absence of the inhibitor?(B)What kind of inhibitor is threo-sphingosine? Explain this type of inhibition.arrow_forwardDraw the (B1-->A1) linked dissacharide formed between the C3 epimer of B-D-glucose and the C2 epimer of a-D-galactose. Explain in 1-2 sentences why (or why not) a precipiate would be observed when mixing this dissacharide in an alkaline solution of copper.arrow_forwardIn addition to the pathway described in Figure 16.31, eukaryotes can also syn- thesize phosphatidylcholine and phosphatidylethanolamine, starting with free choline or ethanolamine, respectively. In this salvage pathway, the phospho- diester linkage in the glycerophospholipid is formed by activating the -OH of the head group instead of the diacylglycerol moiety. Propose a pathway for the synthesis of phosphatidylcholine from free choline using this salvage route.arrow_forward
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