Chapter 25, Problem 8P

Interpretation Introduction

Interpretation:

A balanced equation for the synthesis of glucose from aspartate should be determined.

Concept introduction:

Aspartate is taken into account to be the supply of carbons for gluconeogenesis whereas transamination of aspartate to -ketoglutarate generates salt. Thus, the step that utilizes energy in gluconeogenesis is bypassed once aspartate is metabolized ranging from pyruvate resulting in${\text{CO}}_{\text{2}}$as a product. The reaction is as below:

$\begin{array}{l}{\text{2 Aspartate + 2 α-Ketoglutarate + 2NADH + 6H}}^{\text{+}}{\text{+ 2ATP + 2GTP + 4H}}_{\text{2}}\text{O}\to \\ {\text{Glucose +2 Glutamate + 2NAD}}^{\text{+}}{\text{+ 2ADP + 2GDP + 4P}}_{\text{i}}{\text{ + 2CO}}_{\text{2}}\end{array}$