A mutant is found that has the following protein sequence in that part of the protein: Tyr Lys Gly Arg Thr Cys Ser Premature Stop. What is the likely mutation? Obetween A12 and C13 insert T. between C13 and C14 insert T. OA15 -> del. C13 and C14. -> del. O G8 -> T. G20 -> A. T21 -> del.
A mutant is found that has the following protein sequence in that part of the protein: Tyr Lys Gly Arg Thr Cys Ser Premature Stop. What is the likely mutation? Obetween A12 and C13 insert T. between C13 and C14 insert T. OA15 -> del. C13 and C14. -> del. O G8 -> T. G20 -> A. T21 -> del.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Wild type genomic sequence of a portion of a gene and the wild type sequence of portion of the protein gene
product. The protein sequence only matches partially.
TAT AAA GGG CGA CCA CCT GGT AAT GGG ACT TTG AGG
Tyr Lys Gly Arg Pro Pro Ala Pro Arg Gln Tyr Trp
Note: The five amino acids at the amino end of the WT protein match the coding sequence perfectly, but not
the six at the carboxyl end. This is for an obvious reason that you should figure out before starting the
problem. One of the difficulties with this problem is that you do not have the DNA sequence for the carboxyl
end of the protein, but that should not be a problem! And, so far, there are no mutations; nothing unusual, it is
just a normal eukaryotic gene!!
A mutant is found that has the following protein sequence in that part of the protein:
Tyr Lys Gly Arg Thr Cys Ser Premature Stop. What is the likely mutation?
between A12 and C13 insert T.
O between C13 and C14 insert T.
A15
-> del.
O C13 and C14 -> del.
G8 -> T.
OG20 -> A.
T21 -> del.
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