Which of the following mutations would result in higher than normal expression of the trp genes in presence of tryptophan? OA. Mutations in region 3 that prevent 3-4 stem loop formation B. Mutations in region 1 that prevent 1-2 stem loop formation H C. Mutations in region 2 that prevent 2-3 stem loop formation D. Both a and b OE. None of the above
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
In the trp operon, there are three types of hairpin loop structures made with the respective regions: 1–2, 2–3 or 3–4. This operon contains genes coding for enzymes required for the synthesis of tryptophan when the levels in the cell are low.
The operon is used in such a way that when there is abundant tryptophan present, the operon genes are repressed or blocked. And in case levels are low the genes are activated.
But mutations in above mentioned hairpin structures/regions can alter this normal functioning of the operon and result in different outcomes.
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