A. DNA viruses generally cause malignancy by : inserting themselves in the host DNA, possible because their genome is similar to that of the host activating a cellular growth factor receptor, that activates the signal transduction pathway. inactivating a tumor suppressor gene, that results in uncontrolled proliferation. B. PDGF is overexpressed in certain cancers. This is an example of a mutation in the --- region a. regulatory b. coding

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