In experiments in which rat embryo fibroblasts are transfected with suspected oncogenes, introduction of which of the following genes transform the cells (select one)? A. Myc alone B. H-Ras alone C. E1A alone D. Both Myc and E1A together E. Both Myc and H-Ras together
In experiments in which rat embryo fibroblasts are transfected with suspected oncogenes, introduction of which of the following genes transform the cells (select one)?
| A. |
Myc alone |
|
| B. |
H-Ras alone |
|
| C. |
E1A alone |
|
| D. |
Both Myc and E1A together |
|
| E. |
Both Myc and H-Ras together |
Myc gene basically a proto-oncogene that play a key role in cell cycle progression, cellular transformation and apoptosis. The Ras gene family members for example H-Ras is important in cell signaling. Its primary role involved in cell division regulation. When mutation occurs in Ras genes, the cells grow uncontrollably and cause cancer. Both Myc and Ras activation leads to tumorigenesis. Under some conditions, it triggers the oncogenes causing cellular transformation. As reported through several experiments, combination of both leads to tumorigenesis.
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