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How does the GA(T>C)A mutation in the Duffy promoter provide malaria resistance? Podused Diff

How does the GA(T>C)A mutation in the Duffy promoter provide malaria resistance? Podused Diff

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Understanding the Duffy Promoter Mutation in Malaria Resistance **Question:** How does the GA(T>C)A mutation in the Duffy promoter provide malaria resistance? **Options:** - Reduced Duffy expression is toxic to malarial parasite Plasmodium vivax - Plasmodium vivax can't bind to Endothelial cells - Plasmodium vivax can't bind to Blood Cells - Duffy has no effect on malarial resistance **Explanation:** The Duffy antigen, expressed on red blood cells, acts as a receptor for the malaria parasite Plasmodium vivax. A mutation in the Duffy promoter, specifically GA(T>C)A, can alter this binding process and potentially contribute to malaria resistance by preventing the parasite from attaching and entering the cells.
Transcribed Image Text:### Understanding the Duffy Promoter Mutation in Malaria Resistance **Question:** How does the GA(T>C)A mutation in the Duffy promoter provide malaria resistance? **Options:** - Reduced Duffy expression is toxic to malarial parasite Plasmodium vivax - Plasmodium vivax can't bind to Endothelial cells - Plasmodium vivax can't bind to Blood Cells - Duffy has no effect on malarial resistance **Explanation:** The Duffy antigen, expressed on red blood cells, acts as a receptor for the malaria parasite Plasmodium vivax. A mutation in the Duffy promoter, specifically GA(T>C)A, can alter this binding process and potentially contribute to malaria resistance by preventing the parasite from attaching and entering the cells.
Expert Solution
Step 1: What is Plasmodium vivax?

A protozoan parasite and human pathogen that most frequently causes malaria is known as Plasmodium vivax.

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