5. Treatment of the patients with familial hypercholesterolemia by statins(pravastatin, for instants) allows to decrease cholesterol levels in blood up to thenormal range. Explain the statin action on the cholesterol metabolism. For that:a) draw the scheme of the cholesterol synthesis, indicate the key enzyme of thepathway;b) name all mechanisms of the key enzyme regulation and statin's action;c) describe the structure of LDL receptor and its function in cholesterolmetabolism;d) explain the cause of familial hypercholesterolemia and the symptoms of thedisease.

Familial hypercholesterolemia is an autosomal dominant condition. It is linked to early…

Answered: 5. Treatment of the patients with…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

8. Write the equation for the action of Pancreatin (lipase) on a molecule of Tristearin.
1. 65 years old woman with low physical activity got the excess carbohydrates (about 400 g daily) for several years. The laboratory value of total cholesterol in serum blood was 260 mg/dl. Why the excess consumption of carbohydrates can cause hypercholesterolemia? To answer the question: a) compare the cholesterol concentration in the serum blood of the patient with the normal range; b) draw the schemes of the metabolic pathways confirming that overeating of carbohydrates can result in hypercholesterolemia; c) draw the scheme of the cholesterol synthesis regulation; d) give your prescriptions for the diet and treatment of the patient.
8. In patients with diabetes mellitus type I, the biochemical disorders result from changes in fucl metabolism. One of these signs is acidosis. Explain why such patients have a deviation of blood pH from the norm? For this me the Ocuics, name d) specify the hormone that accelerates this preeursor formation and provide appropriate charts, starting from the hormone binding to adipocyte and concluding with precursor formation, give an explanation to the charts.
15
8. Patients on Irinotecan therapy increase production of hCES2 even though hCES2 breaks it down. (10.1093/inci/div132) Knowing this, How would you think about determining the optimum dosage of both drugs (Irinotecan and Compound 24) in a patient with chronic diarrhea/ulcerative colitis that is being treated for colon cancer? (There are a lot of right answers here). (Remember, Irinotecan and Compound 24 are BOTH binding hCES2).
4. A sportsman is doing a 10 km marathon for 1.5 hours. What changes in lipid metabolism in adipose tissue and muscles are triggered by long-term physical activity? To answer the question: a) name the hormone, controlling the lipid metabolism in adipocytes and write down the scheme of the process; b) explain, how some of the products of lipid mobilization, transported from adipocytes to the bloodstream, would be utilized by skeletal museles and liver in these conditions; c) calculate the ATP yield in the result of palmitolcic acid oxidation.
8. In patients with diabetes mellitus type 1, the biochemical disorders result from changes in fuel metabolism. One of these signs is acidosis, Explain why such patients have a deviation of blood pH from the norm? For this 9. b) write the reactions of synthesis and oxidation of these molecules, name the enzymes, coenzymes, reaction localization: X
8. In patients with diabetes mellitus type I, the biochemical disorders result from changes in fuel metabolism. One of these signs is acidosis. Explain why such patients have a deviation of blood pH from the norm? For this: d) specify the hormone that accelerates this precursor formation and provide appropriate charts, starting from the hormone binding to adipocyte and concluding with precursor formation, give an explanation to the charts.
The DNA sequence ATCAGCGCTGGC is part of a gene. how many amino acids are coded for by this message? 4. 8. 12 20 O Option 5
10. Which pathway leads to the formation of dicarboxylic acids as an end product? A. Beta-oxidation D. Omega-oxidation 11. The major site of formation of acetoacetate from fatty acids is the: A) adipose tissue. B. Pentose Phosphate, oxidative phase E. Kreb's Cycle C. Alpha-oxidation B) intestinal mucosa. C) kidney. D) liver. E) muscle.
6. Provide a biochemical explanation for the fact that some patients with homocystinuria respond to vitamin Bo, while others do not. 7. In addition to the reaction shown in the metabolic pathway, vitamin Bo participates in a considerable number of other metabolic reactions of amino acids. Why does the daily requirement for vitamin Be vary according to the amount of protein in the diet? 1.
2. “Most enzymes are gene-encoded proteins." Using this lens, explain: A) effects of increased temperature on the rate of enzymatic reactions, and B) effects of decreased temperature on enzymatic reactions, and C) importance of optimal pH and ionic strength on enzymatic reactions.

SEE MORE QUESTIONS

Recommended textbooks for you

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781305961135

Author:

Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal

Publisher:

Cengage Learning

Biochemistry

ISBN:

9781305577206

Author:

Reginald H. Garrett, Charles M. Grisham

Publisher:

Cengage Learning

Fundamentals of General, Organic, and Biological …

Biochemistry

ISBN:

9780134015187

Author:

John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson

Publisher:

PEARSON

SEE MORE TEXTBOOKS