10. The patients with a genetically determined medium-chain acyl-CoA dehydrogenase (MCAD) deficiency suffer from episodes of profound fatigue associated with vomiting, which is happening if they fasted for more than 8 hours. They have hypoglycemia, clevated level of free fatty acids in the blood but ketone bodies were below normal. Explain the development of these symptoms. For that answer the question and do the following tasks: a) why hypoglycemia occurs in the patients fasting for more than 8 hours? b) why the level of free fatty acids is elevated in blood? Write the scheme explaining this symptom; c) draw the scheme of fatty acid metabolism, which is blocked in case of this genetic disorder.
10. The patients with a genetically determined medium-chain acyl-CoA dehydrogenase (MCAD) deficiency suffer from episodes of profound fatigue associated with vomiting, which is happening if they fasted for more than 8 hours. They have hypoglycemia, clevated level of free fatty acids in the blood but ketone bodies were below normal. Explain the development of these symptoms. For that answer the question and do the following tasks: a) why hypoglycemia occurs in the patients fasting for more than 8 hours? b) why the level of free fatty acids is elevated in blood? Write the scheme explaining this symptom; c) draw the scheme of fatty acid metabolism, which is blocked in case of this genetic disorder.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Transcribed Image Text:10. The patients with a genetically determined medium-chain acyl-CoA
dehydrogenase (MCAD) deficiency suffer from episodes of profound fatigue
associated with vomiting, which is happening if they fasted for more than
8 hours. They have hypoglycemia, clevated level of free fatty acids in the
blood but ketone bodies were below normal. Explain the development of these
symptoms. For that answer the question and do the following tasks:
a) why hypoglycemia occurs in the patients fasting for more than 8 hours?
b) why the level of free fatty acids is elevated in blood? Write the scheme
explaining this symptom;
c) draw the scheme of fatty acid metabolism, which is blocked in case of this
genetic disorder.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps with 1 images
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON