Inhibitors are important in developing new pharmaceuticals. Two important classes of inhibitors include COX- 2 inhibitors and ACE inhibitors. Use the internet to find the following information: A. What are COX-2 inhibitors used to treat? How are they different from ibuprofen or aspirin? B. What enzyme does the COX-2 inhibitor work on? C. List one commercial product (brand name and chemical name) that is a COX-2 inhibitor. D. What disease is treated by ACE inhibitors? E. List the Substrate, Product and Enzyme that are affected by ACE inhibitors. The peptide bond between what two amino acid residues is broken by this enzyme? F. List one commercial product (brand name and generic name) that is an ACE inhibitor.
Inhibitors are molecules or compounds that reduce the rate of a chemical reaction, or block it completely. They are useful in a wide range of applications, including drug development, manufacturing, and biotechnology. Inorganic inhibitors include acids, bases, chelating agents, and heavy metals. Organic inhibitors include alcohols, esters, amines, and phenols. Enzyme inhibitors are molecules that bind to an enzyme and reduce its activity. Examples include allosteric inhibitors, competitive inhibitors, and non-competitive inhibitors. Other types of inhibitors include metal-ion inhibitors, substrate-site inhibitors, and transition-state analogs. Inhibitors can be reversible or irreversible, depending on their chemical structure. They can also act as activators, by increasing the rate of a reaction. Inhibitors play an important role in various biological processes, including metabolism, regulation of gene expression, and signal transduction.
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