5. From the data in the table below, calculate the rate constant (k) for the degradation of the drug molecule. Pick the best answer for the rate constant. | % Drug Time (h) 93.4 1.38 85.2 3.0 75.9 6.0 A) 0.5/h B) -0.5/h C) 0.05/h D) -0.05/h 63.1 52.5 41.8 8.6 12 17
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- 6. The zero-order rate constant for a drug degradation is 0.05 mg/mL yr. If a 1g/100mL solution is prepared and stored, what is the shelf-life of the drug? A) 2 months B) 20 months C) 2 years D) 20 yearsrug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1A child has been prescribed cefaclor for the treatment of an inner ear infection. Your colleague has calculated that the 21.8 kg patient requires 2.67 mL of cefaclor oral suspension every 12 hours, using the drug label below. Is this a safe dose for the patient?
- What is the Minimum inhibitory concentrations (MIC) for each from 1 to 12 based on the picture:Doris has reconstituted a bottle of Cefprozil® Oral Suspension to fill a patient's prescription. The prescription calls for 400 mg CefprozilⓇq12h for 7 days. Doris needs to know if the amount of reconstituted medication in the bottle will be enough to last the patient for 7 days. Calculate the total amount of medication in the bottle after this medication has been reconstituted: TEVA Seferle, PA 18960 PHARMACEUTICALS USA SHAKE WELL BEFORE USING KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN 5 mL (approx. one teaspoonful) of suspension. Phenylketonurics: This product contains 10.1 mg of phenylalanine per Store constituted suspension in refrigerator. Discard after 14 days Ruv. A 7/2005 L52974 NDC 0093-1075-78 CEFPROZIL for Oral Suspension USP 125 mg/5 mL* Each 5 mL, when constituted according to directions, contains 125 mg anhydrous cetprozil, Ronly 75 mL (when mixed) TEVA To the Pharmacist: Prepare suspension at time of dispensing. Add to the bottle a total of 59 ml water.…Can you show me a graph of drug concentration versus time that includes the loading and maintenance doses, effective and therapeutic concentrations, and including a curve showing a drug dose just below the toxic range, a curve showing a drug dose in and above the therapeutic range, and a curve showing a drug dose that stays just below the therapeutic range?
- Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…Estimate the new dose and dosing interval for morphine, a high extraction ratio drug in a patient with a Child-Pugh score of 8 if the drug is normally given at a dose of 30 mg every 8 hours. A) 7.5 mg every 8 hours B) 22.5 mg every 8 hours C) 30 mg every 6 hours D) 30 mg every 12 hoursUsing conversion factors, solve each of the following clinicalproblems:a. A nurse practitioner prepares an injection of promethazine,an antihistamine used to treat allergic rhinitis. If thestock bottle is labeled 25 mg /mL and the order is a doseof 12.5 mg, how many milliliters will the nurse draw up inthe syringe?b. You are to give ampicillin 25 mg/kg to a child with a massof 62 lb. If stock on hand is 250 mg /capsule, how manycapsules should be given?
- 1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…From an economic point of view, the consultancy firm wanted to calculate the price a patient wouldneed to pay for the full treatment. The cost of each vial of the drug ‘A’ is $450.50 dollar where it contains 30 mg. The usual dose of drug administered is 145 mg once every 2 weeks, during a 12-week period to a patient weighing 190 lb and a height of 6 ft 2 inch. Calculate the cost for the full treatment for the above patient.d.) Dosage forms available in the market (ex. tablet) and matter classification (ex. solid/liquid/gas – homogeneous/ heterogeneous E.)Dosage and regimen (ex. take #1 500 mg tablet every 4 hours) f.)Pharmacologic Use or Indication. of a precipitated sulfur or the one at the third row only? (thank you so much to the experts who's going to answer this and has answered me with the first part this is extremely helpful for me ? sorry for this note ?)