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Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?

Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?
Transcribed Image Text:Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?
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