Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter6: Oral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 7.2P
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Question 1.
The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the
table below to answer the following questions:
Substrate
Km (M)
kcat (S-1)
kz/Km
A
4.0 x 10-4
1.6 x 10+
4.0 x 107
B
6.7 x 10-2
1.75 x 104
2.6 x 105
C
1.1 x 10-3
9.5 x 103
8.6 x 106
a. Organize the substrates from lowest to highest binding affinity. Briefly explain your
answer.
b. Organize the substrates from slowest to fastest product formation. Briefly explain your
answer.
c. For which substrate does the enzyme have the highest catalytic efficiency and why?
Transcribed Image Text:Question 1. The following substrates are metabolized by the same enzyme, Acetylcholinesterase. Use the table below to answer the following questions: Substrate Km (M) kcat (S-1) kz/Km A 4.0 x 10-4 1.6 x 10+ 4.0 x 107 B 6.7 x 10-2 1.75 x 104 2.6 x 105 C 1.1 x 10-3 9.5 x 103 8.6 x 106 a. Organize the substrates from lowest to highest binding affinity. Briefly explain your answer. b. Organize the substrates from slowest to fastest product formation. Briefly explain your answer. c. For which substrate does the enzyme have the highest catalytic efficiency and why?
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