Question 22 2 pts You are a scientist studying the effects of arsenic on muscle cells. You read an article online claiming that arsenic is a competitive inhibitor of pyruvate dehydrogenase. You read another article claiming that arsenic is an allosteric inhibitor of pyruvate dehydrogenase. Match the following observations with the claim they would support if true. A. An effective treatment against arsenic poisoning is the addition of large amounts of pyruvate. Allosteric Inhibitor B. Arsenic binds to pyruvate dehydrogenase at a different site than where pyruvate binds. Competitive Inhibitor C. Arsenic reversibly binds to pyruvate dehydrogenase in the active site. Competitive Inhibitor D. Arsenic has a very different chemical structure than pyruvate. Allosteric Inhibitor

Q: As more inhibitor is added to the enzyme reaction depicted in the graph below, the shift in the…

A: Enzymes are high molecular weight proteins that catalyse biochemical reactions. They contain an…

Q: Draw cartoon representations showing each of the following 3 types of inhibition: competitive,…

A: Enzyme inhibition vital in biochemistry. It manifests in competitive, noncompetitive and…

Q: PMSF is a molecule used in biochemical research. It inactivates serine proteases by binding…

A: PMSF is phenylmethylsulfonyl fluoride which is a serine protease inhibitor.  Competetive inhibitors…

Q: in simple words differentiate non competitive and competitive inhibition.

A: Enzymes are proteins that act as biocatalysts. Enzymes catalyze the biochemical and chemical…

Q: Explain the various forms of enzyme inhibitions in detail, using appropriate examples. Please be…

A: Enzymes bind to substrate molecules through their active site and increase the rate of conversion…

Q: Answer TRUE or FALSE. a. If both the inhibitor and the substrate bind at the active site on a random…

A: Dear students, According to the guidelines, we are attempting the first three subparts of a question…

Q: Why can we say that having a pure noncompetitive inhibitor present is similar to just having less…

A: Enzyme inhibition refers to the decrease in enzyme related processes, enzyme production, or enzyme…

Q: Enzymatic method does not require prior separation of individual sugars. True or False?

A: Enzymes have ability to catalyze specific reactions. Enzymatic methods are rapid, specific and…

Q: Enzyme inhibition (compare and contrast reversible and irreversible inhibitors)

A: Enzyme inhibition is the process by which rate of an enzyme catalyzed reaction is decreased.

Q: Binding of a ligand to protein X affects the binding properties of another site on X. This is an…

A: An enzyme is defined as a biological catalyst or simply a molecule that is typically always a…

Q: Transition-state analogs, which can be used as enzyme inhibitors and to generate catalytic…

A: Compounds resembling the transition state of a catalyzed reaction should be very effective…

Q: How can we tell whether a reversible inhibitor inhibits in a competitive, noncompetitive, or…

A: Reversible inhibition refers to inhibition that does not result in a permanent change in the…

Q: In mixed inhibition as shown below, please draw a lineweaver-burk plot when Kl is greater than KI'.…

A: Michalis Menten equation for given reactionE + S ESE+PVo - Initial velocity or initial reaction…

Q: You are studying an enzyme and wish to determine how an inhibitor functions. The enzyme reaction is…

A: Inhibitors are the substances that bind to enzyme and influence the enzyme activity . There are four…

Q: (c) When [S] = 0.0004, what will Vo be in the absence of inhibitor? (d) When [S] = 0.0004, what will…

A: Km is the MM constant which is used as an affinity measurement for an enzyme. Km is equal to the…

Q: Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms…

A: Nucleotide metabolism is the set of biochemical reactions that involve the synthesis and breakdown…

Q: For an enzymatic reaction, draw curves that show the appropriate relationships between the variables…

A: An enzymatic reaction is a reaction that involves conversion of substrate molecule into product by…

Q: Draw a Lineweaver-Burke plot with two lines, one representing an uninhibited enzyme and another…

A: Competitive inhibition of Lineweaver–Burk plot increases the slope of the line and alters the…

Q: B A Which sketches represent the action of an enzyme? Check none of them if none of them do. B And…

A: There are three sketches 1, 2 and 3 with labelling A, B and C. We need to identify the enzyme action…

Q: A molecule that changes an enzyme's conformation so that its active site elsewhere on the enzyme can…

A: Enzymes function as a catalyst that speeds up a chemical reaction. However, the enzymes themselves…

Q: Why is the transition-state analog not necessarily the same as a competitive inhibitor

A: Competitive inhibitor is the inhibitor having the similar shape as the substrate of the enzyme and…

Q: A nonsense mutation occurs in the AB sequence. What would be the most significant outcome of this?

A: Metabolic pathways- Metabolic pathway is a linked series of chemical reactions occurring within a…

Q: A non-competitive inhibitor can options:   Has no effect on Ks…

A: Has no effect on Ks:True. Non-competitive inhibitors do not change the enzyme's affinity for the…

Q: If you performed a kinetic study of an irreversible inhibitor, such as penicillin, what would you…

A: The apparent Michaelis constant (Km) is unaffected by irreversible inhibitors, however, because the…

Q: T/F Both competitive and noncompetitive inhibitors bind reversibly to an enzyme (E), thereby…

A: Both competitive and noncompetitive inhibitors are reversible inhibitors which are the enzymes that…

Q: The inhibitory effect of an uncompetitive inhibitor is greater at high [S] thanat low [S]. Explain…

A: Uncompetitive inhibitor involves the binding of the inhibitor to the enzyme-substrate complex. An…

Q: Define and contrast competitive and non-competitive inhibition.

A: The enzyme activity can be inhibited by the binding of small molecules or ions. The process by which…

Q: What type of reversible inhibitor are sulfanomides?     Competitive     Uncompetitive…

A: Substrate molecules get converted to product molecules during a biochemical reaction. Enzymes are…

Q: In the diagram below, the orange circle represents an effector and the dark purple shapes (both the…

A: An allosteric effector, also referred to as an allosteric regulator, is defined as a molecule which…

Q: sing equilibrium argument, why does Km apparently increase, decrease or stay the same in…

A: Inhibition in biochemistry occurs in different enzymes. Inhibition of enzymes means blocking or…

Q: Given the active site diagram and reaction mechanism, indicate the mechanism of irreversible…

A: Irreversible inhibition is a process in which inhibitors bind covalently or non-covalently to a…

Q: Allosteric inhibitors can affect enzymes in two ways: by blocking the active site or by changing the…

A: The body's cells may produce a variety of enzymes. However, it turns out that producing and…

Q: Draw and label the Lineweaver–Burk, Plots for each type of inhibitor.

A: The LB plot has 1[S0] as X-axis and 1v0 as Y-axis. In all the below graphs, the GREEN line indicates…

Q: Starting from the situation below, explain the next immediate steps that occur after the agonist…

A: GTP stands for Guanosine Triphosphate. It is a nucleotide which is a molecule composed of a…

Q: Suppose you specifically want to measure the amount of beta-glucose present in a sample. You have…

A: Mutarotation is also called anomerization. The epimers that differ in configuration are called…

Q: Would you expect the structure of a noncompetitive inhibitor of a given enzyme to be similar to that…

A: Non-competitive inhibition is a type of inhibition where the inhibitor reduces the activity of the…

Q: Why does a pure noncompetitive inhibitor not changethe observed KM?

A: The non-competitive inhibitor is a molecule that does not compete with the substrate to get bind to…

Q: How can enzyme inhibition be used in the treatment of certain diseases? Cite examples

A: Introduction: Inhibitors are substances that bind to an enzyme and inhibit its activity. It will…

Q: Reversible inhibition will be _____________ if the inhibitor and substrate bind to the same active…

A: Introduction: An enzyme inhibitor is characterized as a substance that binds with the enzyme and…

Q: draw and label a Michaelis-Menten plot showing the effect of a compentitive inhibitor

A: Two scientists named Leonor Michaelis and Maud Leonora Menten, proposed a model which is known as…

Q: What is the difference between pure and mixed noncompetitive inhibition?

A: Pure competitive inhibition is the type of inhibition in which the inhibitor binds to the site other…

Q: PMSF is a protease inhibitor that binds to enzyme active site. What is the possible mode of…

A: A competitive inhibitor is a molecule that competes with the substrate to get bind to the enzyme…

Q: What step ends the first-half of the chymotrypsin mechanism? Attack of water on the acyl-enzyme…

A: Chymotrypsin is a proteolytic enzyme secreted by the pancreases  in the small intestine.

Q: The ES complex may be destabilized by:

A: NOTE: AS PER OUR GUIDELINES WE ARE ONLY SUPPOSED TO ATTEMPT THE FIRST QUESTION, PLEASE RESUBMIT THE…