Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 14QP: If phenylalanine was not an essential amino acid, would diet therapy (the elimination of...
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Answer the question below

Transcribed Image Text:Answer BOTH parts of this question.
(0
N
-N
Figure Q29
Enalaprilat (Figure Q29) is an important inhibitor of ACE. Using fully
labelled diagrams draw out the interaction of enalaprilat with the active
site of ACE, designating the interactions between the molecule and the
active site correctly (e.g. hydrogen bonding interaction).
(b) Enalaprilat suffers from bioavailability problems. This has led to the
generation of an esterified prodrug variant. Identify the site of the
esterification and explain the rationale for this modification.
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