Answer BOTH parts of this question. N -N Figure Q29 (a) Enalaprilat (Figure Q29) is an important inhibitor of ACE. Using f Li

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Answer BOTH parts of this question.
(0
N
-N
Figure Q29
Enalaprilat (Figure Q29) is an important inhibitor of ACE. Using fully
labelled diagrams draw out the interaction of enalaprilat with the active
site of ACE, designating the interactions between the molecule and the
active site correctly (e.g. hydrogen bonding interaction).
(b) Enalaprilat suffers from bioavailability problems. This has led to the
generation of an esterified prodrug variant. Identify the site of the
esterification and explain the rationale for this modification.
Transcribed Image Text:Answer BOTH parts of this question. (0 N -N Figure Q29 Enalaprilat (Figure Q29) is an important inhibitor of ACE. Using fully labelled diagrams draw out the interaction of enalaprilat with the active site of ACE, designating the interactions between the molecule and the active site correctly (e.g. hydrogen bonding interaction). (b) Enalaprilat suffers from bioavailability problems. This has led to the generation of an esterified prodrug variant. Identify the site of the esterification and explain the rationale for this modification.
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