is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?
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is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?
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- Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?explain why the protein binding of the drug is not correlated with the distribution or elimination parameters?rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
- Explain how the Kirby-Bauer test works and what information it provides. Define minimum inhibitory concentration (MIC). Describe how the E-test works and what information it provides.why is there a difference between the stock solution concetration of chymotrypsin calculated from zero time y intercepts versus the stock solution label information?Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-life
- Clonazepam 1 MG Oral Tablet [Klonopin] - Dose: 1 tablet Generic name and popular Trade name(s) for this drug Drug classification What is this drug typically used for? Describe the pharmacokinetics of the drug: Onset (O) Peak (P) Duration (D) Half-life (1/2) Metabolized where (M) Excreted (E) Major side effect and/or Adverse Reactions of the drug? Nursing Implications (What do you need to assess, know or plan for with this medication?) Patient Education (What will you tell the patient and family about this drug? What do you need to teach the patient or family to safely take this medication)Why is there a difference between the stock solution concentration of chymotrypsin calculated from zero time y-intercepts versus the stock solution label information?Consider the following release data for a drug in water Q (Cumulative amount released in mg/cm?) Time (min) 15 12 30 16 45 20 60 23 120 32 240 46 480 65 1. On MS Excel , Plot Q Vs t, and Q Vs vt in separate graphs. Determine the equation and R2 for each curve. solve Q2 only show me by steps 2. Based on the R for the graphs, which release pattern does the drug follow, and why?
- Using conversion factors, solve each of the following clinical problems:a. The physician has ordered 1.0 g of tetracycline to be given every six hours to a patient. If your stock on hand is 500-mg tablets, how many will you need for one day’s treatment?b. An intramuscular medication is given at 5.00 mg / kg of body weight. What is the dose for a 180-lb patient?c. A physician has ordered 0.50 mg of atropine, intramuscularly. If atropine were available as 0.10 mg /mL of solution, how many milliliters would you need to give?d. During surgery, a patient receives 5.0 pt of plasma. How many milliliters of plasma were given?Which of the following is incorrect about blood glucose test interpretation A) fasting plasma glucose 6.1-6.8 defined as having IGT and should probably be screened again after a year or so. B) 2 results>7mmmol/l defined as having diabetes C) fasting plasma glucose >6mmol, recall for further test. D) fasting or random plasma glucose, on one reading of <11.1mmol/l is diagnostic of diabetesOnly 13.40
