is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?
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is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?
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- A single dose of 300mg of drug is 63% bioavailable by the IM route. The same drug is 42% bioavailable by the oral route. How many 150mg tablets would need to be administered PO BID to achieve plasma levels comparable to the IM dose?Suppose the EC50 value--the drug concentration necessary for half of a maximal effect to occur--is not the same as the equilibrium dissociation constant, Kd. Where would it lie on a dose-response curve?explain why the protein binding of the drug is not correlated with the distribution or elimination parameters?
- drug is risperidone Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life intervals. Provide the equations used. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; the antibiotic ketoconazole, classified as a “potent inhibitor of CYP3A4” in the AMH. the herbal medicine St John’s wort, is classified as an “inducer of CYP3A4” in the AMH;…rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?
- Explain how the Kirby-Bauer test works and what information it provides. Define minimum inhibitory concentration (MIC). Describe how the E-test works and what information it provides.why is there a difference between the stock solution concetration of chymotrypsin calculated from zero time y intercepts versus the stock solution label information?Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-life
- Why is there a difference between the stock solution concentration of chymotrypsin calculated from zero time y-intercepts versus the stock solution label information?Consider the following release data for a drug in water Q (Cumulative amount released in mg/cm?) Time (min) 15 12 30 16 45 20 60 23 120 32 240 46 480 65 1. On MS Excel , Plot Q Vs t, and Q Vs vt in separate graphs. Determine the equation and R2 for each curve. solve Q2 only show me by steps 2. Based on the R for the graphs, which release pattern does the drug follow, and why?An experiment was carried out to measure the reaction rate of hydrolysis of acetylcholme (substrate) with serum enzymes (Eadie, 1949). In the experiment, two experiments were conducted, namely experiment 1 without using a prostigmine inhibitor and experiment 2 using a prostigmine inhibitor at 1.5 x 10^-7 mol/l. the data obtained are: a. Is prostigmine competitive or noncompetitive inhibitor? b. determine the value of km and rmax for the two experiments, compare
