The citric acid cycle includes a series of enzyme-catalyzed reactions that occur in the mitochondria and makes up the third stage of the catabolism ofbiomolecules. Answer the following questions. Use comma to separate the names of each intermediate where applicable.Part 1 of 2Which intermediate(s) in the citric acid cycle contain(s) two chirality centers?0,0,...Part 2 of 2×Which intermediate(s) contain(s) a 2° alcohol?3,0,...

Part 1:The intermediate in the citric acid cycle that contains two chirality centers is Isocitrate.A…

Answered: The citric acid cycle includes a series…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The reaction pictured is an oxidation-reduction reaction in the citric acid cycle in which the energy-carrier molecule NADH is generated. Identify which molecule in the reaction will be oxidized and which molecule will be reduced. Place a single answer choice in each box. COO- HO-C-H H-C-H COO- Malate NAD+ NADH + H+ Oxidized malate oxaloacetate COO- H-C-H ī COO- Oxaloacetate Reduced NADH NAD+
Perform a pyruvate dehydrogenase reaction and a single turn of the citric acid cycle using an oxaloacetate molecule uniformly labeled with 18O and one pyruvate molecule uniformly labeled with 14C. Highlight the fate of all radioactively labeled atoms when complete.
a) Describe the three irreversible reactions of the Citric Acid Cycle. Ensure to indicate their purpose/role, the substrates and products, the enzyme involved, and any significant features of the reaction. b) Why are these reactions considered irreversible (why can't they be reversed)? c) Using one of the reactions as an example, explain why it is important for the cell that the reaction is irreversible.
Does any step of the citric acid cycle directly produce ATP? Explain.
Using the following diagram, a. name all the steps in citric acid cycle. (What are the intermediates) b. Is glycolysis endothermic or exothermic. Thanks
The citric acid cycle is frequently described as the major pathway of aerobic catabolism, which means that it is an oxygen-dependent degradative process. However, none of the reactions of the cycle directly involve oxygen as a reactant. Why is the pathway oxygen dependent?
What reaction serves to link glycolysis and the citric acid cycle, and what is the enzyme that catalyzes the reaction?
Mitochondria are important organelles for energy production. Why do mitochondria contain dehydrogenases?
You are carrying out an experiment in the lab to study the citric acid cycle. To do this, you add 14C-labeled pyruvate at carbon 3 (this is the methyl carbon) to metabolically active mitochondria. Based on your knowledge of the citric acid cycle, what is the location of the 14C-label in oxaloacetate after one turn of the cycle? How many turns of the cycle are required to release all of the the14C-label as CO2? Be sure to justify your answers using a thorough description, as your answer does not need to include any drawings of the intermediates (but, feel free to include one if you wish).
The citric acid cycle generates NADH and FADH2, which are then used in the process of oxidative phosphorylation to make ATP. If the citric acid cycle (which does not use oxygen) and oxidative phosphorylation are separate processes, as they are, then why is it that the citric acid cycle stops almost immediately when O2 is removed?
The coenzymes NAD+ and NADP+ are important electron carriers that pick up electrons from one pathway and deliver them to another. Below is a list of pathways or enzyme complexes that we have covered in class. Indicate which coenzyme these pathways or complexes produce by writing NAD+, NADP+, NADH or NADPH in the blank provided. ________ glycolysis ________ citric acid cycle ________ alcoholic fermentation ________ pyruvate dehydrogenase complex ________ gluconeogenesis ________ mitochondrial electron transport ________ photosynthesis light reactions ________ photosynthesis dark reactions
match the cofactor with its function in the citric acid cycle by entering the number corresponding with the function. A given function may be used more than one time or not at all. Use from the following list of functions to fill in the table below: carries O2 carries small carbon-containing molecules carries e- carries small nitrogen-containing molecules Cofactor Function NAD+/NADH FAD/FADH2 CoA thiamine biotin

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