5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 Possible explanations: 6 11 14 9
5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 Possible explanations: 6 11 14 9
Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter18: The Cardiovascular System: Blood
Section: Chapter Questions
Problem 1ILQ: Visit this site (http://openstaxcollege.org/l/normallevels) for a list of normal levels established...
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Transcribed Image Text:5. For each of the following tables, indicate all of the possibilities from the list that might explain
the dose- or concentration-dependent kinetics observed for each substance, administered to
the same.
Each scenario has at least one but no more than three correct answers.
List of Explanations
1. Saturated plasma protein binding.
II. Saturation of hepatic metabolism.
III. Saturation of active tubular secretion.
IV. Saturation of active tubular reabsorption.
V. Saturation of P-glycoprotein pumps.
a) Total bioavailability with increasing oral dose of xenobiotic
Area under curve
Single oral dose (mg)
125
250
500
1000
(plasma concentration versus time)
62
121
294
804
Possible explanations:
b) Biliary elimination with increasing dose:
Single sublingual dose (mg)
Amount (mg) excreted unchanged in 48hr
100
11.1
200
19.8
400
21.2
Possible explanations:
c) Steady-state plasma concentration with increasing rate of infusion
IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L)
50
100
200
Possible explanations:
6
11
14
9
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