Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 25, Problem 25RQ
Which of these beverages does not have a diuretic effect?
- tea
- coffee
- alcohol
- milk
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 25 Solutions
Anatomy & Physiology
Ch. 25 - Diabetes insipidus or diabetes mellitus would most...Ch. 25 - The color of urine is determined mainly by...Ch. 25 - Production of less than 50 mL/day of urine is...Ch. 25 - Peristaltic contractions occur in the ________....Ch. 25 - Somatic motor neurons must be ________ to relax...Ch. 25 - Which pan of the urinaiy system is not completely...Ch. 25 - The renal pyramids are separated from each other...Ch. 25 - The primary structure found within the medulla is...Ch. 25 - The right kidney is slightly lower because...Ch. 25 - Blood filtrate is captured in the lumen of the...
Ch. 25 - What are the names of the capillaries following...Ch. 25 - The functional unit of the kidney is called...Ch. 25 - ________ pressure must be greater on the capillary...Ch. 25 - Production of urine to modify plasma makeup is the...Ch. 25 - Systemic blood pressure must stay above 60 so that...Ch. 25 - Aquaporin channels are only found in the...Ch. 25 - Most absorption and secretion occurs in this part...Ch. 25 - The fine tuning of water recovery or disposal...Ch. 25 - Vasodilation of blood vessels to the kidneys is...Ch. 25 - When blood pressure increases, blood vessels...Ch. 25 - Which of these three paracrine chemicals cause...Ch. 25 - What hormone directly opposes the actions of...Ch. 25 - Which of these is a vasoconstrictor? nitric oxide...Ch. 25 - What signal causes the heart to secrete atrial...Ch. 25 - Which of these beverages does not have a diuretic...Ch. 25 - Progesterone can bind to receptors for which...Ch. 25 - Renin is released in response to ________....Ch. 25 - Which step in vitamin D production does the kidney...Ch. 25 - Which hormone does the kidney produce that...Ch. 25 - If there were no aquaporin channels in the...Ch. 25 - What is suggested by the presence of white blood...Ch. 25 - Both diabetes mellitus and diabetes insipidus...Ch. 25 - Why are females more likely to contract bladder...Ch. 25 - Describe how forceful urination is accomplished.Ch. 25 - What anatomical structures provide protection to...Ch. 25 - How does the renal poital system differ from the...Ch. 25 - Name the structures found in the renal hilum.Ch. 25 - Which structures make up the renal corpuscle?Ch. 25 - What are the major structures comprising the...Ch. 25 - Give the formula for net filtration pressure.Ch. 25 - Name at least five symptoms of kidney failure.Ch. 25 - Which vessels and what pail of the nephron are...Ch. 25 - Give the approximate osmolarity of fluid in the...Ch. 25 - Explain what happens to Na+ concentration in the...Ch. 25 - If you want the kidney to excrete more Na+ in the...Ch. 25 - What organs produce which hormones or enzymes in...Ch. 25 - PTH affects absorption and reabsorption of what?Ch. 25 - Why is ADH also called vasopressin?Ch. 25 - How can glucose be a diuretic?Ch. 25 - How does lack of protein in the blood cause edema?Ch. 25 - Which three electrolytes are most closely...
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