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3. In muscle cells, the AG for glucose+ AT P glucose-6-P+ADP is -33.5 kJ mol-1. In contrast, the AG for glucose - 6- P fructose - 6- P is -2.5 k.J mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose – 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose - 6– P2 fructose - 6 - P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?

3. In muscle cells, the AG for glucose+ AT P glucose-6-P+ADP is -33.5 kJ mol-1. In contrast, the AG for glucose - 6- P fructose - 6- P is -2.5 k.J mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose – 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose - 6– P2 fructose - 6 - P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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3. In muscle cells, the AG for glucose+ ATP 2 glucose – 6-P+ADP is –33.5 kJ mol-1. In contrast, the AG for glucose – 6 – P fructose – 6 – P is -2.5 kJ · mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose - 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – P2 fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?
Transcribed Image Text:3. In muscle cells, the AG for glucose+ ATP 2 glucose – 6-P+ADP is –33.5 kJ mol-1. In contrast, the AG for glucose – 6 – P fructose – 6 – P is -2.5 kJ · mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose - 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – P2 fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?
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