In muscle cells, the AG for glucose+ATP = glucose– 6–P+ADP is –33.5 kJ·mol-1. In contrast, the AG for glucose – 6 – P 2 fructose – 6 – P is –2.5 kJ· mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose – 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – PZ fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?
In muscle cells, the AG for glucose+ATP = glucose– 6–P+ADP is –33.5 kJ·mol-1. In contrast, the AG for glucose – 6 – P 2 fructose – 6 – P is –2.5 kJ· mol-1. (a) In a physiological context, which reaction is faster? How do you know? (b) The enzyme that catalyzes glucose + ATP 2 glucose – 6 – P + ADP (hexokinase) is an important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – PZ fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which to regulate glycolysis relative to phosphoglucose isomerase?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
![In muscle cells, the AG for glucose+ATP2 glucose-6-P+ADP is –33.5 kJ•mol-'. In contrast,
the AG for glucose – 6 – P fructose – 6 - P is –2.5 kJ · mol-1.
(a) In a physiological context, which reaction is faster? How do you know?
(b) The enzyme that catalyzes glucose + ATP 2 glucose
important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – PZ
fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which
to regulate glycolysis relative to phosphoglucose isomerase?
6 – P + ADP (hexokinase) is an
|
-
|](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa6c5565a-787b-43d3-b23e-780453faf6da%2F4bcb2bfc-374d-429c-b676-9c7f75119e51%2Fgqfzuog_processed.png&w=3840&q=75)
Transcribed Image Text:In muscle cells, the AG for glucose+ATP2 glucose-6-P+ADP is –33.5 kJ•mol-'. In contrast,
the AG for glucose – 6 – P fructose – 6 - P is –2.5 kJ · mol-1.
(a) In a physiological context, which reaction is faster? How do you know?
(b) The enzyme that catalyzes glucose + ATP 2 glucose
important point of regulation in glycolysis, while the enzyme that catalyzes glucose – 6 – PZ
fructose – 6 – P (phosphoglucose isomerase) is not. Why is hexokinase a good step at which
to regulate glycolysis relative to phosphoglucose isomerase?
6 – P + ADP (hexokinase) is an
|
-
|
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