3. a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pka's and pl. **Please use the pka table provided at the end of this problem set, so we are all using the same numbers! C. What is the pI of the PEACH peptide? (show your work below) d. The charge of the PEACH peptide at pH 3= at pH 7= and at pH 10=
3. a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pka's and pl. **Please use the pka table provided at the end of this problem set, so we are all using the same numbers! C. What is the pI of the PEACH peptide? (show your work below) d. The charge of the PEACH peptide at pH 3= at pH 7= and at pH 10=
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:**Amino Acid pKa Values Table**
This table provides the pKa values for the amino acids, representing their ionizable groups. These values are essential in determining the ionization states of amino acids at different pH levels, which play critical roles in protein structure and function.
| 1-Letter | pK1 | pK2 | pK side chain |
|----------|-----|-----|--------------|
| A | 2.35| 9.87| |
| C | 1.92| 10.7| 8.37 |
| D | 1.99| 9.90| 3.90 |
| E | 2.10| 9.47| 4.07 |
| F | 2.20| 9.31| |
| G | 2.35| 9.78| |
| H | 1.80| 9.33| 6.04 |
| I | 2.32| 9.76| |
| K | 2.16| 9.06| 10.54 |
| L | 2.33| 9.74| |
| M | 2.13| 9.28| |
| N | 2.14| 8.72| |
| P | 1.95| 10.54| |
| Q | 2.17| 9.13| |
| R | 1.82| 8.99| 12.48 |
| S | 2.19| 9.21| |
| T | 2.09| 9.10| |
| V | 2.29| 9.74| |
| W | 2.46| 9.41| |
| Y | 2.20| 9.21| 10.46 |
### Explanation of the Table Columns:
- **1-Letter:** The one-letter abbreviation for each amino acid.
- **pK1:** The pKa value for the carboxyl group (-COOH) of the amino acid.
- **pK2:** The pKa value for the amino group (-NH3+) of the amino
![### Problem 3
#### a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code).
#### b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pKa's and pI.
**Please use the pKa table provided at the end of this problem set, so we are all using the same numbers!**
[There is a blank grid provided for drawing the titration curve.]
#### c. What is the pI of the PEACH peptide? __________ (show your work below)
#### d. The charge of the PEACH peptide at pH 3 = __________, at pH 7 = __________, and at pH 10 = __________.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcd7a0374-f414-4e0c-9a39-f312d4f3b754%2Fc8ea1d6d-360f-495c-a6bb-a62b6787a735%2F389q4i4_processed.jpeg&w=3840&q=75)
Transcribed Image Text:### Problem 3
#### a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code).
#### b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pKa's and pI.
**Please use the pKa table provided at the end of this problem set, so we are all using the same numbers!**
[There is a blank grid provided for drawing the titration curve.]
#### c. What is the pI of the PEACH peptide? __________ (show your work below)
#### d. The charge of the PEACH peptide at pH 3 = __________, at pH 7 = __________, and at pH 10 = __________.
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