Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
3. a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pka's and pl. **Please use the pka table provided at the end of this problem set, so we are all using the same numbers! C. What is the pI of the PEACH peptide? (show your work below) d. The charge of the PEACH peptide at pH 3= at pH 7= and at pH 10=

3. a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pka's and pl. **Please use the pka table provided at the end of this problem set, so we are all using the same numbers! C. What is the pI of the PEACH peptide? (show your work below) d. The charge of the PEACH peptide at pH 3= at pH 7= and at pH 10=

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
**Amino Acid pKa Values Table** This table provides the pKa values for the amino acids, representing their ionizable groups. These values are essential in determining the ionization states of amino acids at different pH levels, which play critical roles in protein structure and function. | 1-Letter | pK1 | pK2 | pK side chain | |----------|-----|-----|--------------| | A | 2.35| 9.87| | | C | 1.92| 10.7| 8.37 | | D | 1.99| 9.90| 3.90 | | E | 2.10| 9.47| 4.07 | | F | 2.20| 9.31| | | G | 2.35| 9.78| | | H | 1.80| 9.33| 6.04 | | I | 2.32| 9.76| | | K | 2.16| 9.06| 10.54 | | L | 2.33| 9.74| | | M | 2.13| 9.28| | | N | 2.14| 8.72| | | P | 1.95| 10.54| | | Q | 2.17| 9.13| | | R | 1.82| 8.99| 12.48 | | S | 2.19| 9.21| | | T | 2.09| 9.10| | | V | 2.29| 9.74| | | W | 2.46| 9.41| | | Y | 2.20| 9.21| 10.46 | ### Explanation of the Table Columns: - **1-Letter:** The one-letter abbreviation for each amino acid. - **pK1:** The pKa value for the carboxyl group (-COOH) of the amino acid. - **pK2:** The pKa value for the amino group (-NH3+) of the amino
Transcribed Image Text:**Amino Acid pKa Values Table** This table provides the pKa values for the amino acids, representing their ionizable groups. These values are essential in determining the ionization states of amino acids at different pH levels, which play critical roles in protein structure and function. | 1-Letter | pK1 | pK2 | pK side chain | |----------|-----|-----|--------------| | A | 2.35| 9.87| | | C | 1.92| 10.7| 8.37 | | D | 1.99| 9.90| 3.90 | | E | 2.10| 9.47| 4.07 | | F | 2.20| 9.31| | | G | 2.35| 9.78| | | H | 1.80| 9.33| 6.04 | | I | 2.32| 9.76| | | K | 2.16| 9.06| 10.54 | | L | 2.33| 9.74| | | M | 2.13| 9.28| | | N | 2.14| 8.72| | | P | 1.95| 10.54| | | Q | 2.17| 9.13| | | R | 1.82| 8.99| 12.48 | | S | 2.19| 9.21| | | T | 2.09| 9.10| | | V | 2.29| 9.74| | | W | 2.46| 9.41| | | Y | 2.20| 9.21| 10.46 | ### Explanation of the Table Columns: - **1-Letter:** The one-letter abbreviation for each amino acid. - **pK1:** The pKa value for the carboxyl group (-COOH) of the amino acid. - **pK2:** The pKa value for the amino group (-NH3+) of the amino
### Problem 3 #### a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). #### b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pKa's and pI. **Please use the pKa table provided at the end of this problem set, so we are all using the same numbers!** [There is a blank grid provided for drawing the titration curve.] #### c. What is the pI of the PEACH peptide? __________ (show your work below) #### d. The charge of the PEACH peptide at pH 3 = __________, at pH 7 = __________, and at pH 10 = __________.
Transcribed Image Text:### Problem 3 #### a. Draw the structure (at physiological pH) of the peptide PEACH (note that this is one letter amino acid code). #### b. Draw the titration curve for the PEACH peptide. Make sure to label the axes and identify the pKa's and pI. **Please use the pKa table provided at the end of this problem set, so we are all using the same numbers!** [There is a blank grid provided for drawing the titration curve.] #### c. What is the pI of the PEACH peptide? __________ (show your work below) #### d. The charge of the PEACH peptide at pH 3 = __________, at pH 7 = __________, and at pH 10 = __________.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps with 1 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Membrane chemistry
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS