2. The following tyrosine-phosphorylated polypeptides were tested as substrates of proteintyrosine phosphatase, an important enzyme in cellular signal transduction. The pTyr in boldsignifies the tyrosine residue that is phosphorylated. The binding affinities of the polypeptidesubstrates to the enzyme were found to follow the order: (a) > (c) - (d) >> (b).(a) Asp-Ala-Asp-Glu-pTyr-Leu-lle-Pro-Gln-Gln-Gly(b) Pro-Val-Pro-Glu-pTyr-lle-Asn-Ala-Ser-Val(c) Asp-Ala-Glu-Glu-pTyr-Leu-Val-Pro-Gln-Gln-Gly(d) Asp-Asn-Leu-Tyr-pTyr-Trp-Asp-Glu-Asn-Ser-SerIn addition to the presence of the phosphorylated tyrosine residue, what amino acida)properties of the polypeptides accounts for the relative order of binding affinities to the enzyme?b)the active site of the phosphatase enzyme that are responsible for the affinity of substratebinding? Assume a pH of 7.4 at the enzyme active site. (Note a phosphatase uses phosphate substrate)What amino acids have side chains that would indicate they are likely to be present in

Name: 2. The following tyrosine-phosphorylated polypeptides were tested as
Uploaded: 2024-03-20T06:42:41.000Z
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Description: 2. The following tyrosine-phosphorylated polypeptides were tested as substrates of proteintyrosine phosphatase, an important enzyme in cellular signal transduction. The pTyr in boldsignifies the tyrosine residue that is phosphorylated. The binding a