You are working on a protein with the following sequence in an area of interest. -Asp-Leu-Leu-Gln-Glu-Glu-Asp-Glu-Ser-Arg a. The current structure, solved at pH 7.4, of this segment has an alpha helix that is disrupted a er the Gln. Why might the alpha helix stop at this residue? b. This protein is involved in Lysosomes in vivo. The secondary structure of this region is expected to change into a complete alpha helix. Why might this change into a complete helix? ( Hint: Lysosomes are acidic!)
Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
3) You are working on a protein with the following sequence in an area of interest.
-Asp-Leu-Leu-Gln-Glu-Glu-Asp-Glu-Ser-Arg
a. The current structure, solved at pH 7.4, of this segment has an alpha helix that is
disrupted a er the Gln. Why might the alpha helix stop at this residue?
b. This protein is involved in Lysosomes in vivo. The secondary structure of this region is
expected to change into a complete alpha helix. Why might this change into a complete
helix? ( Hint: Lysosomes are acidic!)
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