2. Complete the following table summarizing the 4 major types of xenobiotic receptor targets discussed in class and their generalized characteristics. lon channel Cellular localization Effect of agonist binding to the receptor Major effector molecules or downstream targets (if required) Example mechanism of receptor down- or up-regulation Cell membrane Neuromuscular junctions and neuronal synapses G-coupled Protein Receptor Receptor Tyrosine Kinase Nuclear Receptor Receptor changes conformation, intracellular domain recruits/activates G- protein DNA hormone response element – regulates transcription of targeted genes Provide a specific example of this type of receptor Nicotinic acetylcholine receptor Down-regulation: continued activation leads to auto- phosphorylation of intracellular domains, promoting ubiquitination that targets receptors for proteosomal degradation

2. Complete the following table summarizing the 4 major types of xenobiotic receptor targets discussed in class and their generalized characteristics. lon channel Cellular localization Effect of agonist binding to the receptor Major effector molecules or downstream targets (if required) Example mechanism of receptor down- or up-regulation Cell membrane Neuromuscular junctions and neuronal synapses G-coupled Protein Receptor Receptor Tyrosine Kinase Nuclear Receptor Receptor changes conformation, intracellular domain recruits/activates G- protein DNA hormone response element – regulates transcription of targeted genes Provide a specific example of this type of receptor Nicotinic acetylcholine receptor Down-regulation: continued activation leads to auto- phosphorylation of intracellular domains, promoting ubiquitination that targets receptors for proteosomal degradation

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter6: Cell Communication

Section6.4: Signal Transduction

Problem 6LO: Trace the sequence of events in signal transduction for each of the following second messengers:...

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