H =0 H 0: R HN AN H R 0 2 the H 0-04 + R HN N R R HN N -R -O-OH H 0 H 2 1 2. Tryptophan in a peptide chain is a major target of singlet oxygen. Please provide two possible products of the reaction of '02 with tryptophan and a mechanism for their formation. Note that the benzene ring is unreactive. R -NH ΙΖ R 102 Two products N H Tryptophan in a peptide

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1.  Amino acid analysis of the peptide gave the following residues: Asp Leu Lys Met Phe Tyr. The following facts were observed: Trypsin treatment had no effect. The phenylthiohydantoin released by Edman degradation was  C-C-CH2. Brief chymotrypsin treatment yielded several products including a dipeptide and a tetrapeptide. The tetrapeptide contained Leu, Lys and Met is some order. Cyanogen bromide treatment afforded a dipeptide, a tetrapeptide and a free Lys. What is the amino acid sequence for this heptapeptide?

The S3’ pocket on PfSUB1 (attached) contains the side chains of Lys465 and Tyr427. Researchers discovered that the Km for substrates with acidic residues in the P3’ position are much lower than those with nonpolar resides at the P3’ position in PfSUB1. Explain the Km data.