Answered: - cys TIIL Tyr- HN ·O-H. Но HN HO. он…

- cys TIIL Tyr- HN ·O-H. Но HN HO. он LO.H он .OH. HN H. HN 0-1 klo-H HO но он OH LOH. OH. H 1. HN 0 من بر он H HN но он 0 LOH. 吉

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter2: Basic Hematology

Section2.13: Erythrocyte Sedimentation Rate

Problem 1CS

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Question

Can you check if I did it correctly

what is a step-by-step mechanism of the transformation of the epoxy intermediate to the final para-hydroxy benzene product.

The drug Atorvastatin (brand name is Lipitor, used to lower cholesterol levels) is shown below. This molecule is rapidly metabolized (+ = 14 hours) by Cytochrome P450 to a para-hydroxy derivative of the benzene ring attached to the amide group (this is followed by reaction of the acid group with glucose and excretion via bile). The Cytochrome P450-catalyzed metabolic process occurs via an epoxide intermediate.

-
cys
TIIL
Tyr-
HN
·O-H.
Но
HN
HO.
он
LO.H
он
.OH.
HN
H.
HN
0-1
klo-H
HO
но
он
OH
LOH.
OH.

Chemical pathways by which living things function, especially those that provide cellular energy, such as the transformation of energy from food into the energy of ATP. Metabolism also focuses on chemical pathways involving the synthesis of new biomolecules and the elimination of waste.

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