Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
- cys TIIL Tyr- HN ·O-H. Но HN HO. он LO.H он .OH. HN H. HN 0-1 klo-H HO но он OH LOH. OH. H 1. HN 0 من بر он H HN но он 0 LOH. 吉

- cys TIIL Tyr- HN ·O-H. Но HN HO. он LO.H он .OH. HN H. HN 0-1 klo-H HO но он OH LOH. OH. H 1. HN 0 من بر он H HN но он 0 LOH. 吉

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question

Can you check if I did it correctly

what is a step-by-step mechanism of the transformation of the epoxy intermediate to the final para-hydroxy benzene product.

The drug Atorvastatin (brand name is Lipitor, used to lower cholesterol levels) is shown below. This molecule is rapidly metabolized (+ = 14 hours) by Cytochrome P450 to a para-hydroxy derivative of the benzene ring attached to the amide group (this is followed by reaction of the acid group with glucose and excretion via bile). The Cytochrome P450-catalyzed metabolic process occurs via an epoxide intermediate.

- cys TIIL Tyr- HN ·O-H. Но HN HO. он LO.H он .OH. HN H. HN 0-1 klo-H HO но он OH LOH. OH.
Transcribed Image Text:- cys TIIL Tyr- HN ·O-H. Но HN HO. он LO.H он .OH. HN H. HN 0-1 klo-H HO но он OH LOH. OH.
H 1. HN 0 من بر он H HN но он 0 LOH. 吉
Transcribed Image Text:H 1. HN 0 من بر он H HN но он 0 LOH. 吉
Expert Solution
steps

Step by step

Solved in 2 steps with 2 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS