Suppose the EC50 value--the drug concentration necessary for half of a maximal effect to occur--is not the same as the equilibrium dissociation constant, Kd. Where would it lie on a dose-response curve?
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Suppose the EC50 value--the drug concentration necessary for half of a maximal effect to occur--is not the same as the equilibrium dissociation constant, Kd. Where would it lie on a dose-response curve?
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- is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?The following dose-response curve depicts the physiological response to a drug or combination of drugs as a function of agonist concentration. First, post an explanation of the different curves noted in regards to the type of each drug administered. There may be more than one answer.An 84 year old male patient has been given a loading dose of digoxin of 298 micrograms in divided doses by intravenous infusion. He has a creatinine clearance (Ccr) of 34 ml / min. What is the maintenance dose (in micrograms) that this patient should receive? Round your answer to the nearest whole number. Use the formula provided to calculate the maintenance dose. Maintenance Dose = Peak body stores x % daily loss 100 Where: Peak Body Stores = Loading Dose % Daily Loss = 14 + Creatinine clearance (Ccr) 5
- A particular drug has first-order elimination rate kinetics and follows a one-compartment model. Which of the following plots would you expect to result in a curved line? A. plasma concentration versus time B. natural log of plasma concentration versus time ( for pharmaceutical formulation module)A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.The absolute bioavailability of clonazepam is about 90%. This sentence tells us that the value of ____ for clonazepam is 0.9. (A) F (B) FF (C) FG (D) FH
- Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7.Give your answer to the nearest whole number of micrograms.The equation below can be used:Loading Dose = Cp desired x VdS x FCan you show me a graph of drug concentration versus time that includes the loading and maintenance doses, effective and therapeutic concentrations, and including a curve showing a drug dose just below the toxic range, a curve showing a drug dose in and above the therapeutic range, and a curve showing a drug dose that stays just below the therapeutic range?The initial plasma concentration of a drug given iv at 8:00am is 210 mg/ml. If the half life of the drug is 6 hours, what will the plasma concentration be at 7:00pm that same day?
- drug is risperidone Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life intervals. Provide the equations used. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; the antibiotic ketoconazole, classified as a “potent inhibitor of CYP3A4” in the AMH. the herbal medicine St John’s wort, is classified as an “inducer of CYP3A4” in the AMH;…Give typed explanationA 31-year-old woman was diagnosed with serious endogenous depression and was started on treatment with intramuscular imipramine. Imipramine has a FIM of 100%, and a Va of 1134 L. The effective (plasma] for its antidepressant effect is 0.2 mg/L. Calculate the intramuscular dose (in mg) that would be required to successfully achieve the desired effect in this patient. (Use the "square root of x button" to enter math equations in order to show your work.)