Suppose the EC50 value--the drug concentration necessary for half of a maximal effect to occur--is not the same as the equilibrium dissociation constant, Kd. Where would it lie on a dose-response curve?
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Suppose the EC50 value--the drug concentration necessary for half of a maximal effect to occur--is not the same as the equilibrium dissociation constant, Kd. Where would it lie on a dose-response curve?
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- is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?A single dose of 300mg of drug is 63% bioavailable by the IM route. The same drug is 42% bioavailable by the oral route. How many 150mg tablets would need to be administered PO BID to achieve plasma levels comparable to the IM dose?
- Can two drugs have the same EC50 but different efficacy on a dose-response curve?rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1A 71-year-old man with enterococci infection is started treatment with 240 mg of intravenous gentamicin. It has a volume of distribution of 30 L, a half-life of 4 hours, and demonstrates first-order and one-compartment kinetics. Which of the following is the most likely serum drug concentration 8 hours later? 0.5 mg/L 1 mg/L 1.5 mg/L 2 mg/L 3 mg/L
- In the dose response curve below, Drug B has [ Select ] potency and [ Select ] efficacy as Drug A A B Log drug dose ResponseAn 84 year old male patient has been given a loading dose of digoxin of 298 micrograms in divided doses by intravenous infusion. He has a creatinine clearance (Ccr) of 34 ml / min. What is the maintenance dose (in micrograms) that this patient should receive? Round your answer to the nearest whole number. Use the formula provided to calculate the maintenance dose. Maintenance Dose = Peak body stores x % daily loss 100 Where: Peak Body Stores = Loading Dose % Daily Loss = 14 + Creatinine clearance (Ccr) 5A particular drug has first-order elimination rate kinetics and follows a one-compartment model. Which of the following plots would you expect to result in a curved line? A. plasma concentration versus time B. natural log of plasma concentration versus time ( for pharmaceutical formulation module)
- Your doctor is determining which drug would best treat your ailment - a drug with a low dissociation constant and a few significant side effects or a drug with a high dissociation constant and many mild side effects. There's no perfect choice, so they go with the first choice. What does this mean for you? A) You'll need a relatively low dose of the drug to be effective and chances of side effects are low B) You'll need a relatively high dose of the drug but the chances of side effects are low. C) You'll need a relatively high dose of the drug but the side effects are not expected to be harmful D) You'll need a relatively low dose of the drug but the risk of side effects is high.A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.Consider the following release data for a drug in water Q (Cumulative amount released in mg/cm?) Time (min) 15 12 30 16 45 20 60 23 120 32 240 46 480 65 1. On MS Excel , Plot Q Vs t, and Q Vs vt in separate graphs. Determine the equation and R2 for each curve. solve Q2 only show me by steps 2. Based on the R for the graphs, which release pattern does the drug follow, and why?