10. What are the steps involved in the ubiquitination of proteins? (select all that apply)a. E1 activates ubiquitin by hydrolyzing ATP to ADP and Pi to generate a thioester bond betweenubiquitin C-terminus and an E1 Cysteine residueb.E1 activates ubiquitin by hydrolyzing ATP to AMP and PPI to generate a thioester bond betweenubiquitin C-terminus and an E1 Cysteine residuec. E1 transfers activated ubiquitin to E2 enzymes through a transthioesterification reactiond. E2 enzymes directly add ubiquitin to substratee. E2 enzymes directly add ubiquitin to HECT E3 Ligasesf. E2 enzymes directly add ubiquitin to RING E3 Ligasesg. E2 enzymes directly add ubiquitin to substrate bound to HECT E3 Ligasesh. E2 enzymes directly add ubiquitin to substrate bound to RING E3 Ligases11. How is ubiquitination regulated? (select all that apply)a. Substrate selection for ubiquitination is mediated by E1 enzymesb. Substrate selection for ubiquitination is mediated by E2 enzymesc. Substrate selection for ubiquitination is mediated by E3 enzymesd. Deubiquitinases act as 'erasers' of the ubiquitin posttranslational modificatione. Lysine residues of substrates can be protected from ubiquitination by being posttranslationallymodified by a different posttranslational modification

Name: 10. What are the steps involved in the ubiquitination of proteins? (s
Uploaded: 2024-03-20T06:42:41.000Z
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Description: 10. What are the steps involved in the ubiquitination of proteins? (select all that apply)a. E1 activates ubiquitin by hydrolyzing ATP to ADP and Pi to generate a thioester bond betweenubiquitin C-terminus and an E1 Cysteine residueb.E1 activates ub