The CFTR protein is a chloride channel in the cell membrane. Use your understanding of the biochemical properties/categories of amino acids and how they interact with membrane phospholipids to predict the distribution of charged/polar, and non-polar amino acids within the domains of CFTR listed below. Consider one category to include the charged amino acids and the polar amino acids and the other category to include the non-polar amino acids. For each domain, predict which category of amino acids is likely to be most abundant. Also, explain the rationale behind your prediction. Protein domain Prediction (Charged/Polar or Non-Polar amino acids?) Explanation for prediction TMD1 and TMD2 (transmembrane domains, parts 1-12)     ECLs and ICLs (extracellular and intracellular loops)         NBD1 and NBD2         R

Q: Which of the following must be true based on the data below for ligand L binding to protein A and to…

A: Proteins are biomolecules which catalyzes most of the biochemical reactions in all living cells and…

Q: Distinguish between transmembrane proteins, integral proteins, and peripheral proteins.

A: Membrane proteins are present on the plasma membrane. These are of three types- 1.  integral…

Q: For a protein that binds multiple ligands with negative cooperativity, which of the following is…

A: The ligand binds to its target molecule

Q: The Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of…

A: All amino acids are of different property based on their property they present on the cytoplasmic…

Q: Suppose that you are studying a protein involved in transporting ions in and out of cells. Would you…

A: Transport proteins are the type of membrane proteins that help in the transport of certain ions and…

Q: attached to the polypeptides keep the amino acid chains in an extended configuration. extending…

A: Biomolecules are organic molecules that take part in various biochemical reactions. These are mainly…

Q: Choose the statements that describe how the helix orients in the tertiary structure of an integral…

A: Plasma membrane is made up of mainly phospholipid and protein. Membrane protein can be classified as…

Q: Uncharged molecules can passively pass through membranes more readily than charged molecules.…

A: An acid dissociation constant  (Ka) is a quantitative measure of the strength of an acid in the…

Q: 13. What value do N-linked saccharides serve for membrane surface proteins? Which amino acid…

A: N-linked saccharides, also known as N-linked glycans, play several crucial roles in the function of…

Q: What are lipid rafts? Describe the molecular components

A: As per the honor code, we only answer one question at a time. Therefore we are answering the first…

Q: 5. The diagram on the right illustrates experimental results taken from a publication by Peter…

A: A substance which generally disrupts in mitochondria, the coupling between ATP synthesis and…

Q: 12. What value do O-linked saccharides serve for membrane surface proteins? Which amino acid…

A: O-linked saccharides, also known as O-linked glycans, are carbohydrates that are attached to…

Q: Which ligand-binding curve in the figure below would be consistent with the protein exhibiting a Ka…

A: Consider the interaction between a protein (P) and ligand (L) as shown below.Here, Ka is the…

Q: 7.What is an allosteric effect? What is are homotropic and heterotropic allostery? Name one example…

A: Q. 8. ANSWER. (a) θ (Theta): This represents the fraction of protein molecules that bind to the…

Q: a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues that can…

A: Hello. Since your question has multiple sub-parts, we will solve first three sub-parts for you. If…

Q: The hydropathy plot of a particular hyaluronan synthase is plotted by Heldermon et al and is shown…

A: The hydropathy plot helps the researchers give the understanding of the degree of hydrophobicity or…

Q: Please describe the hydrophobic effect and its contribution to membrane protein folding

A: The hydrophobic effect being the major driving force for the membrane protein folding

Q: Match amino to possible function or role in a membrane protein. (Choose the best answer) Interact…

A: Amino acids are the compound of C, H, O, N and S. An amino acid consists of a carboxylic group, an…

Q: 81. You have used the primary amino acid sequence of a newly identified protein (of unknown…

A: This question is about hydropathy plot . The hydropathy plot displays the hydrophobic and…

Q: Proteins have many functions in the cell membrane. Which function is NOT related to a protein?…

A: The proteins are one of the major component of phospholipid bilayer that form the biological…

Q: Read This! When phospholipids are added to an aqueous environment (consisting mostly of water) the…

A: Introduction  Cells are box or chamber-like structures containing fluid cytoplasm enclosed by…

Q: A certain protein is used to activate myosin. If the protein is treated with B-mercaptoethanol, it…

A: Proteins are biomolecules made up of amino acid chains arranged in three-dimensional and…

Q: Describe a two-step purification procedure that could be used to purify/isolate protein A from the…

A: Chromatography is a laboratory technique used to separate mixtures of different components. It works…

Q: 2. The following tyrosine-phosphorylated polypeptides were tested as substrates of protein tyrosine…

A: Enzymes are proteins that catalyze various reactions inside the cellular environment. Enzyme binds…

Q: HELP

A: Of the proteins listed, the function of Na+/K+ ATPase is most likely to be affected in the low…

Q: 1. Theoretically, a protein could assume a virtually infinite number of configurations and…

A: Since you have posted multiple questions, we will provide the solution only to the first question as…

Q: A. What change should disrupt the interaction between proteins 1 and 2 the most? Why? B. What…

A: Introduction: Proteins are the polymers of L-α-amino acids. Proteins plays an important role in the…

Q: 5. Refer to Model 2 for information relevant to this question. A sample of the peptide Lys net…

A: Amino acids are organic compound having two functional group namely carboxyl and amino group. Some…

Q: . Theoretical and experimental measurements show that in many cases, the contributions of ionic and…

A: The amino acid sequence of the polypeptide/protein is the primary structure of the protein. The…

Osmosis

In simple words, osmosis is the slow, gradual movement of a liquid through a membrane. But there are nuances to this process. For instance, there has to be an imbalance in the distribution of solute in the liquid on either side of the membrane, which has to be semipermeable. The liquid in the region with a lower solute concentration moves to the region with a higher concentration, thereby displacing the solution in the process. The objective is to equalize the concentration of molecules on both sides of the membrane; the displacement of liquid can be viewed as a byproduct of this equalization. Since there is no energy required to carry osmosis, it is considered a passive process.