The hydropathy plot of a particular hyaluronan synthase is plotted by Heldermon et al and is shown below. From this plot, Heldermon et al circled six putative (or predicated) membrane domains (PMDs).  Circle the six regions in the plot above you believe could be transmembrane domains of the protein and indicate why you chose those regions.  Please include a description of what information a hydropathy plot gives researchers.

Q: Some types of tumors express cell-surface receptors that are specific for unique peptide sequences.…

A: Of these 9 amino acids, 7 amino acids(H,W,S,Y,L,P,G) will be carrying a positive charge at pH 4. At…

Q: The steroid progesterone has an important role in the female reproductive system. Researchers…

A: "Since you have asked multiple questions, we will solve the first three questions for you. If you…

Q: The Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of…

A: All amino acids are of different property based on their property they present on the cytoplasmic…

Q: 1 0.8 0.6 Mutant y 0.4 Wild-Type 0.2 40 60 80 [ligand] 20

A: According to the given information, the wild type protein structure has aspartate in its primary…

Q: Sphingolipid storage diseases (sphingolipidoses) are inherited diseases caused by abnormal…

A: Sphingolipid storage disease  are caused by the accumulation of the undegradable sphingolipids and…

Q: The predominant forms of actin inside a cell are ATP–G-actin and ADP–F-actin. Explain how the…

A: these are cytoskeletal membrane protein

Q: Given the melting profile of a membrane bilayer consisting of (see attached diagrams) where R =…

A: The graph here has degree of fluidity as Y-axis and temperature as X-axis. The curve will shift to…

Q: The shape of these peptide amphiphiles can be roughly. approximated by three cylindrical regions…

A: The peptide can have hydrophilic regions which means they are water-loving residues or regions that…

Q: The following RNA sequence represents a small messenger which can be translated in a prokaryotic…

A: The first step in translating an RNA sequence into a protein is to divide the sequence into codons,…

Q: Members of the integrin family are the major cell surface receptors for many ECM proteins such as…

A: Integrins are a family of αβ heterodimers. Integrins are cellular adhesion receptor molecules that…

Q: ead Cells have oligosaccharides displayed on their cell surface that are important for cell-cell…

A: The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid…

Q: e (x) if the following statements about synthesis of proteins containing an ER sequence are True or…

A: Signal sequences are present on the N terminal of most of the secretory proteins which are destined…

Q: a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues that can…

A: Hello. Since your question has multiple sub-parts, we will solve first three sub-parts for you. If…

Q: For each of the following, describe the path the protein takes to its final destination in the cell.…

A: Abstract The seven-transmembrane protein, Smoothened (SMO), has shown to be critical for the…

Q: Consider the hypothetical serine protease in the image, which shows the specificity pockets. The S,…

A: Proteases:  These are enzymes that cleave peptide bonds of an amino acid chain of the protein. In…

Q: affinity

A:

Q: Polypeptides with the ER Signal Sequence (MMSFVSLLLVGILFTATEAEQLTKCEVFQ <- one-letter amino acid…

A: Proteins are synthesized in the cytosol in a process called translation. RNA polymerase and other…

Q: What is a KDEL motif?   A The KDEL motif functions as a stop-transfer sequence in Type I membrane…

A: The KDEL receptor is a protein with seven transmembrane domains that was discovered about 20 years…

Q: Genetic testing of a 29-month-old boy shows a mutation in the Phe residue at position 508 in the…

A: Cystic fibrosis is a fatal genetic disease which is caused due to defect in CF transmembrane…

Q: In frogs, when the nucleus of an intestinal cell of a tadpole is transferred to an egg whose nucleus…

A: Nuclear transplantation, also known as nuclear transfer, is a laboratory technique used to transfer…

Q: Trace the pathway of a protein from translation to the plasma membrane. You may name this protein…

A: Membrane proteins are a part of membrane structure, which are very important for a cell to carry out…

Q: Can I get a visual (drawn on paper or on a software; like chem draw or chem sketch)? Illustrate…

A: Activation of the SAM:Activate the carboxyl groups using carbodiimide chemistry.Reagents: EDC…

Q: In the protein adenylate kinase, the C-terminal region has the sequence Val-Asp-Asp-Val-Phe-…

A: A helical wheel representation is a type of plot or visual representation used to illustrate the…

Q: The addition of poly(U) is important in the degradation of mRNAs encoding which of the following…

A: The addition of poly(U) refers to the process of adding a string of uridine (U) nucleotides to the…

Q: Finally, discuss the consequences of 9.2 uM for actin polymerization in a cell, considering critical…

A: A discussion of the consequences of actin concentration on polymerization in a cell, taking into…

Q: Once the chains of peptides that make up lysyl-tRNA synthetase protein are synthesized in ribosomes,…

A: Protein folding is the process where the proteins fold themselves to come to their native form. This…