Consider the hypothetical serine protease in the image, which shows the specificity pockets. The S, pocket has a glutamic acid in the bottom, the S2 pocket is small and hydrophobic, and the S1' pocket is deep and hydrophobic. Suggest a 3-amino acid sequence that this protease would cleave and indicate between which sites the peptide bond would be broken. S2 Which sequence would this protease cleave? O Leu-Val-Arg O Arg-Val-Leu Val-Leu-Arg Val-Arg-Leu O Leu-Arg-Val O Arg-Leu-Val

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Consider the hypothetical serine protease in the image,
which shows the specificity pockets. The S1 pocket has a
glutamic acid in the bottom, the S2 pocket is small and
hydrophobic, and the S1' pocket is deep and hydrophobic.
Suggest a 3-amino acid sequence that this protease would
cleave and indicate between which sites the peptide bond
would be broken.
S2
Which sequence would this protease cleave?
O Leu-Val-Arg
Arg-Val-Leu
Val-Leu-Arg
Val-Arg-Leu
O Leu-Arg-Val
O Arg-Leu-Val
W
Ma
étv N
894
Transcribed Image Text:Consider the hypothetical serine protease in the image, which shows the specificity pockets. The S1 pocket has a glutamic acid in the bottom, the S2 pocket is small and hydrophobic, and the S1' pocket is deep and hydrophobic. Suggest a 3-amino acid sequence that this protease would cleave and indicate between which sites the peptide bond would be broken. S2 Which sequence would this protease cleave? O Leu-Val-Arg Arg-Val-Leu Val-Leu-Arg Val-Arg-Leu O Leu-Arg-Val O Arg-Leu-Val W Ma étv N 894
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