Can I get a visual (drawn on paper or on a software; like chem draw or chem sketch)?Illustrate detailed chemical scheme for how you will functionalize your biomolecule to the surface of the sensor (e.g. if you wanted to functionalize a protein to a gold SPR chip, you should could show the assembly of an amine-terminated SAM, followed by carbodiimide coupling of. the protein). These schemes should be drawn using a chemical illustration software package (ChemDraw / ChemSketch).Your chemical schemes should be as detailed as necessary to accurately depict the chemical design of your system, DO NOT INCLUDE a step-wise mechanism, it is not necessary. You should include at least one literature reference to support your conjugation strategy. 1) [50%] A protein-functionalized sensor for the capture and detection of a specific protein, hapten,immunoglobulin, viral or bacterial analyte (e.g. an antibody-functionalized QCM sensor for the detection of prionproteins). [HINT: The sensor surface should be functionalized WITH a protein to detect another biomolecule. Thetarget molecule you are detecting need not be a protein]2) [50%] A carbohydrate-functionalized sensor for the capture of a specific protein, bacterial or viral target(e.g. a human milk glycan functionalized SPR chip for the capture of norovirus capsids). [HINT: Your sensor shouldbe functionalized WITH a carbohydrate. The target molecule does not need to be a carbohydrate]

Activation of the SAM:Activate the carboxyl groups using carbodiimide chemistry.Reagents: EDC…

Answered: 1) [50%] A protein-functionalized…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Can I get a visual (drawn on paper or on a software; like chem draw or chem sketch)?

Illustrate detailed chemical scheme for how you will functionalize your biomolecule to the surface of the sensor (e.g. if you wanted to functionalize a protein to a gold SPR chip, you should could show the assembly of an amine-terminated SAM, followed by carbodiimide coupling of. the protein). These schemes should be drawn using a chemical illustration software package (ChemDraw / ChemSketch).Your chemical schemes should be as detailed as necessary to accurately depict the chemical design of your system, DO NOT INCLUDE a step-wise mechanism, it is not necessary. You should include at least one literature reference to support your conjugation strategy.