. You have identified a mutation in yeast, a unicellular eukaryote, that prevents the capping of the 5′ end of theRNA transcript. However, much to your surprise, all theenzymes required for capping are normal. You determine that the mutation is, instead, in one of the subunitsof RNA polymerase II. Which subunit is mutant, andhow does this mutation result in failure to add a cap toyeast RNA?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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. You have identified a mutation in yeast, a unicellular eukaryote, that prevents the capping of the 5′ end of the
RNA transcript. However, much to your surprise, all the
enzymes required for capping are normal. You determine that the mutation is, instead, in one of the subunits
of RNA polymerase II. Which subunit is mutant, and
how does this mutation result in failure to add a cap to
yeast RNA?

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