Some prion-related diseases, such as familial fatal insomnia, areinherited. How would you expect the mutation has altered the PrPgene in this case? Would it have affected the promoter, the regulatorysequences, or the coding sequence of the PrP gene?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Some prion-related diseases, such as familial fatal insomnia, are
inherited. How would you expect the mutation has altered the PrP
gene in this case? Would it have affected the promoter, the regulatory
sequences, or the coding sequence of the PrP gene?
Familial fatal insomnia is a medical condition characterized by insomnia or trouble sleeping. This prion disease is caused due to mutation in the gene that encodes PrPC proteins. This protein helps in the normal functioning of the nervous system and also regulates short term and long term memory.
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