Custom eBook for Organic Chemistry
Custom eBook for Organic Chemistry
2nd Edition
ISBN: 9798214171104
Author: Straumanis
Publisher: Cengage Custom
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Chapter NW1, Problem 22CTQ
Interpretation Introduction

Interpretation: Two-letter suffix appears to be common to the names of all side chains should be named.

Concept introduction: Organic compound that consists of only carbon and hydrogen atoms in them are called hydrocarbons. These can either be saturated or unsaturated. Saturated hydrocarbons are compounds that contain only single bonds between them while hydrocarbons with multiple bonds are called unsaturated hydrocarbons. Alkanes are saturated hydrocarbons with general formula of CnH2n+2 , where n is the number of carbon atoms.

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Heparin is used as an anti-coagulant. A risk of heparin use is thrombocytopenia, or low platelet count. This risk is minimized with the use of low molecular weight heparins (LMWH), therefore it is desirable to separate LMWH from higher molecular weight heparins. The method of choice to do this is molecular exclusion chromatography. Below is a chromatogram from a molecular exclusion chromatographic run. Peaks ranging from A to J are clearly distinguishable. The heparin mixture that was analyzed had anywhere from 6 to 30 repeat units of monomer (where the heparin with 30 repeat units would be roughly five times the size of the heparin with six repeat units). a. Which letter most likely represents the peak with 6 repeat units given these heparin polymers were separated with molecular exclusion chromatography? b. Explain your reasoning describing the mechanism of retention in molecular exclusion chromatography. 100 80 60 60 Relative Abundance 40 40 E GH 20 20 B A 36 38 40 42 44 46 48 50 50…
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