Seeley's Anatomy & Physiology
11th Edition
ISBN: 9781259254963
Author: Jennifer Regan (author), Andrew Russo (author), Rod Seeley (author) Cinnamon Vanputte (author)
Publisher: McGraw Hill Higher Education
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Chapter 9, Problem 11RAC
Summary Introduction
Introduction:
The neuromuscular junction is the region where motor neuron axon branches come in contact with the muscle fiber. Acetylcholinesterase is a molecule that prevents acetylcholine, a neurotransmitter, from getting accumulated within the synaptic cleft. This does not allow acetylcholine to act as a constant stimulus at the motor-endplate and thereby producing continuous muscle fiber contraction.
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If acetylcholinesterase fails to function properly at the neuromuscular junction, which of the following would be a consequence?
Death of the lower motor neuron
Saltatory conduction stops
Sodium channels do not open
Constant muscle cell contraction
hen an action potential arrives at the nerve terminal of a neuromuscular junction, which of the following statements best describes the events that occur?
Depolarisation of the nerve terminal causes the release of ACh which activates nicotinic receptors on the skeletal muscle membrane to cause Ca2+ entry and muscle contraction.
Depolarisation of the nerve terminal opens voltage-gated Ca2+ channels, Ca2+ entry brings vesicles containing ACh to the membrane which form fusion pores causing the release of ACh which activates voltage-gated Na+ channels at the end-plate.
Depolarisation of the nerve terminal opens voltage-gated Ca2+ channels, Ca2+ entry brings vesicles containing ACh to the membrane which form fusion pores causing the release of ACh which binds to muscarinic receptors at the end plate.
Depolarisation of the nerve terminal opens voltage-gated Ca2+ channels, Ca2+ entry brings vesicles containing ACh to the membrane which form fusion pores…
A motor unit associated with the stimulation of skeletal muscle is designated as a 1:8 motor unit. Which of the following statements is correct?
The motor unit consists of one somatic neuron and 8 myofibers (muscle fibers)
Each of the myofibers in the motor unit is innervated by more than one neuron
It is part of the autonomic nervous system
The neuron in the motor unit is an afferent neuron
Chapter 9 Solutions
Seeley's Anatomy & Physiology
Ch. 9.1 - List and describe the functions performed by...Ch. 9.1 - State the functions of smooth and cardiac muscle...Ch. 9.1 - Using table 9.1, distinguish among skeletal,...Ch. 9.2 - Identify the four specialized functional...Ch. 9.2 - Outline the differences in control and function...Ch. 9.3 - Name the connective tissue layers that surround...Ch. 9.3 - What are motor neurons? How do the axons of motor...Ch. 9.3 - What is the origin of muscle fibers? How do you...Ch. 9.3 - What are T tubules and the sarcoplasmic reticulum?Ch. 9.3 - Prob. 10AYP
Ch. 9.3 - Prob. 11AYPCh. 9.3 - Prob. 12AYPCh. 9.3 - Prob. 13AYPCh. 9.3 - Prob. 14AYPCh. 9.3 - Prob. 15AYPCh. 9.3 - Prob. 16AYPCh. 9.3 - Prob. 17AYPCh. 9.4 - What type of ion channel contributes to the...Ch. 9.4 - What are the two types of gated ion channels in...Ch. 9.4 - Prob. 20AYPCh. 9.4 - Prob. 21AYPCh. 9.4 - List the two types of voltage-gated channels the...Ch. 9.4 - Prob. 23AYPCh. 9.4 - Prob. 24AYPCh. 9.4 - Prob. 25AYPCh. 9.4 - Prob. 26AYPCh. 9.4 - Describe the structure of a neuromuscular...Ch. 9.4 - Prob. 28AYPCh. 9.4 - Prob. 29AYPCh. 9.4 - Prob. 30AYPCh. 9.4 - Prob. 31AYPCh. 9.4 - What ion is necessary for movement of the...Ch. 9.4 - Describe the steps in cross-bridge cycling. How is...Ch. 9.4 - Prob. 34AYPCh. 9.5 - List the phases of a muscle twitch, and describe...Ch. 9.5 - Prob. 36AYPCh. 9.5 - Prob. 37AYPCh. 9.5 - Prob. 38AYPCh. 9.5 - Prob. 39AYPCh. 9.5 - How does the lack of on unresponsive period in...Ch. 9.5 - Distinguish between active tension and passive...Ch. 9.5 - Prob. 42AYPCh. 9.5 - Prob. 43AYPCh. 9.5 - What is muscle tone, and how is it maintained?Ch. 9.6 - Contrast the structural and physiological...Ch. 9.6 - Prob. 46AYPCh. 9.6 - Prob. 47AYPCh. 9.6 - What factors contribute to increases in muscle...Ch. 9.6 - Prob. 49AYPCh. 9.6 - Prob. 50AYPCh. 9.7 - What is fatigue? List the three locations where...Ch. 9.7 - Prob. 52AYPCh. 9.7 - Prob. 53AYPCh. 9.7 - List the energy sources used to synthesize ATP for...Ch. 9.7 - Prob. 55AYPCh. 9.7 - Prob. 56AYPCh. 9.7 - Prob. 57AYPCh. 9.7 - Prob. 58AYPCh. 9.8 - Describe a typical smooth muscle cell. How do its...Ch. 9.8 - Prob. 60AYPCh. 9.8 - Prob. 61AYPCh. 9.8 - Compare visceral smooth muscle and multiunit...Ch. 9.8 - Prob. 63AYPCh. 9.8 - Prob. 64AYPCh. 9.8 - How are spontoneous contractions produced in...Ch. 9.8 - Prob. 66AYPCh. 9.8 - Prob. 67AYPCh. 9.8 - Prob. 68AYPCh. 9.9 - Prob. 69AYPCh. 9.9 - Prob. 70AYPCh. 9.10 - Prob. 71AYPCh. 9 - Which of these is true of skeletal muscle? a....Ch. 9 - Prob. 2RACCh. 9 - Prob. 3RACCh. 9 - Each myofibril Is made up of many muscle fibers....Ch. 9 - Prob. 5RACCh. 9 - Which of these statements about the molecular...Ch. 9 - Prob. 7RACCh. 9 - Prob. 8RACCh. 9 - Prob. 9RACCh. 9 - Prob. 10RACCh. 9 - Prob. 11RACCh. 9 - Prob. 12RACCh. 9 - Prob. 13RACCh. 9 - With stimuli of increasing strength, which of...Ch. 9 - Considering the force of contraction of a skeletal...Ch. 9 - Which of these events occurs during the lag...Ch. 9 - Prob. 17RACCh. 9 - Prob. 18RACCh. 9 - Given the conditions: (1) low ATP levels (2)...Ch. 9 - Prob. 20RACCh. 9 - Prob. 21RACCh. 9 - Prob. 22RACCh. 9 - Prob. 23RACCh. 9 - Prob. 24RACCh. 9 - Which of these statements concerning aging and...Ch. 9 - Prob. 1CTCh. 9 - A patient is thought to be suffering from either...Ch. 9 - Design an experiment to test the following...Ch. 9 - Explain what is happening at the level of...Ch. 9 - Predict the shape of an active tension curve for...Ch. 9 - Prob. 6CTCh. 9 - Prob. 7CTCh. 9 - Prob. 8CTCh. 9 - Prob. 9CTCh. 9 - Prob. 10CTCh. 9 - Prob. 11CTCh. 9 - Prob. 12CT
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- When an action potential arrives at the neuromuscular junction, acetylcholine is released into the synaptic cleft and binds to receptors in the postsynaptic membrane. Which of the following represents the correct order of the next series of events? A. An action potential travels down the T tubules, depolarization spreads through the T tubules, Ca2+ is released from the sarcoplasmic reticulum, and myosin binds to actin. B. Ca2+ is released from the sarcoplasmic reticulum, an action potential travels down the T tubules, depolarization spreads through the T tubules, and myosin binds to actin. C. An action potential travels down the T tubules, depolarization spreads through the T tubules, Ca2+ is taken up by the sarcoplasmic reticulum, and myosin binds to actin. D. T tubules are depolarized, Ca2+ is released from the sarcoplasmic reticulum, an action potential is created in the muscle cell, and myosin bonds to actin. E. An action potential travels…arrow_forwardWhat system will reset the membrane potential after an action potential has moved along the sarcolemma? acetylcholine receptors Na+-K+ pump desmosomes voltage-gated Ca2+ channelsarrow_forwardFrom the following choices, choose the THREE, that would result in prevention of muscle contraction (in other words, which three descriptive changes below would result in flaccid paralysis of a muscle). exocytosis of acetylcholine is constant, even without action potential injection of botulinum toxin calcium cannot be pumped back into the terminal cisternae acetylcholine receptor remains open to sodium active sites on actin a permanently exposed dramatically increase the activity of acetylcholinesterase calcium cannot bind troponinarrow_forward
- Place the events at the neuromuscular junction in the order in which they occur: 1. release of acetylcholine (ACh) 2. activation of ACH receptors on the motor endplate 3. termination of the ACh activity by acetylcholinesterase 4. arrival of an action potential at the synaptic end bulb 5. diffusion of ACh across the synaptic cleft 6. opening of NA* channels in the motor endplate 7. production of a muscle fiber action potential O 4,1,2,5,6,7,3 4,1,5,6,2,7,3 4,1,5,2,7,6,3 4,1,5,2,6,7,3arrow_forwardPut in order the steps of activation, excitation and contraction of skeletal muscle.arrow_forwardThe axon of neurons contains microtubules with the minus end situated toward the cell body and the plus end situated toward the end of the axon. Neurotransmitters are transported in vesicles carried by motor proteins. A neuron missing which of the following motor proteins would be unable to secrete neurotransmitters in this way? Group of answer choices: Myosin Kinesin Dyneinarrow_forward
- Why does damage to upper motor neurons cause spasticity and muscle cramps? Extracellular calcium is decreased lower motor neurons are over excited Lengthens sarcomeres and thus increase tension Cause synaptic fatigue Neuromuscular junction is disruptedarrow_forwardCurare is a dangerous poison extract from plants that can block the binding site of Acetylcholine receptor channels in neuromuscular junctions. Which of the following molecular events will curare directly inhibit or prevent from occurring? Action potential traveling down the sarcoplasmic reticulum End-plate potential forming Release of calcium ions from the sarcoplasmic reticulum Release of Acetylcholine from axon terminalsarrow_forwardWhich of the following pairs of terms is correctly matched? Voltage-gated calcium channels : presynaptic cell membrane EPP : action potential Acetylcholinesterase : presynaptic cell membrane Achetylcholine exocytosis : motor end platearrow_forward
- Botulism is a disease that was associated to eating out of cans that had been contaminated by a deadly bacteria. It is an anaerobic bacteria (does not need oxygen to survive). What botulism does is It floods hte area with sodium O prevents the sarcoplasmic reticulum from releasing Calcium O prevent the release of the neurotransmitter acetylcholine prevent the release of the neurotransmitter dopaminearrow_forwardWhich of the following step(s) about the excitation of skeletal muscle is/are incorrect? 1. Acetylcholine is released and binds to motor end plate receptors 2. An action potential is created and moves down T-tubules 3. Calcium is released from the sarcoplasmic reticulum 4. Calcium ions bind to tropomyosin to shift troponin off the binding sites for cross-bridging 5. Myosin forms cross-bridges and binds with actin to pull it towards middle of sarcomerearrow_forwardCurare blocks acetylcholine receptors at the motor end plate. What would be the effect of this drug on muscle contraction? increased stimulation of the muscle. more acetylcholinesterase production. lack of Ca2+ uptake by the muscle fiber. inability of the muscle fiber to respond to nervous stimulation. sustained contraction of the muscle.arrow_forward
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