(a) Interpretation: Role of glu, tyr and asp should be identified. Concept introduction: Glutamine can also be denoted by E 117 and act as General acid catalyst in 1 s t step and helps in the catalysis of acid whereas it act as General base catalyst in another step. Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base. Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

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Answer 1

Question

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

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Answer 2

Question

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

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Answer 3

Question

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Expert Solution & Answer

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Answer 4

Question

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Expert Solution & Answer

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Answer 5

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 6

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 7

Chapter 8, Problem 23P

Interpretation Introduction

(a) Interpretation:

Role of glu, tyr and asp should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 8

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 9

Interpretation Introduction

(b) Interpretation:

Effect of mutation of glu to ala on K_m should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 10

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 11

Interpretation Introduction

(c) Interpretation:

How R374 stabilises the transition state should be identified.

Concept introduction:

Glutamine can also be denoted by E 117 and act as General acid catalyst in 1^s^t step and helps in the catalysis of acid whereas it act as General base catalyst in another step.

Glutamine is consist of carboxyl group which attacks the hydroxyl of sialic acid and thus it act as a base catalyst and then it turns into carboxyl group whereas aspartic acid contains amino group which looses electrons to sialic acid and behaves as base.

Nuraminidase is an enzyme helps in hydrolysis of sialic acid which is present on cell surface as binded protein.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 8 - Prob. 1P Ch. 8 - The enzyme urease catalyzes the hydrolysis of urea...Ch. 8 - An enzyme contains an active site aspartic acid...Ch. 8 - The folding and unfolding rate constants for a...Ch. 8 - In some reactions, in which a protein molecule is...Ch. 8 - Would you expect an “enzyme” designed to bind to...Ch. 8 - The initial rate for an enzyme-catalyzed reaction...Ch. 8 - a. If the total enzyme concentration in Problem 7...Ch. 8 - Prob. 9P Ch. 8 - Prob. 10P

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