Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 5, Problem 67TQ
Summary Introduction
To review:
The advantages of the activation of p53 by factors like ER stress, UV ligh, tnd hypoxia.
Introduction:
p53 (codes for a protein of molecular weight 53 kilodaltons) is atumor suppressor gene. A synthesized protein is an example of an intrinsicallyunstructured protein. It regulates the expression of a lot of genes involved in cancer suppression processes. Several factors, such as ER (endoplasmic reticulum) stress, UV (ultraviolet) light, and hypoxia (low oxygen concentration), are known to activate this gene.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
When was the dihydropyridine calcium channel blocker isradipine first patented and by whom? Please provide information on the origin and history of isradipine and who owns it/manufactures it.
9) Below, there is a representation of an SDS-PAGE gel. Assuming the samples in the
MW standard have masses of: 66 kDa, 45 kDa, 36 kDa, 29 kDa, 24 kDa, 20.1 kDa, and
14.2 kDa,
a) Figure 4: indicate where each of the measurements were taken and label as in II.6.
figure 2 above.
b) As in II.7. Table 1 above create Table 2 using the data below. Determine the r.f.
values for the MW standards, plot the relative mobility versus the log of the mass
for the standards, and use the best fit straight line to determine the molecular
weights of the proteins in the whey, peak 1, and peak 2 lanes. (5 pts—this will be
scaled up appropriately if your gel did not develop properly)
dye
MW
Whey
Peak 1 Peak 2
what are the different classes and some examples of neuroprotectants that can be used to treat, prevent, or combat neurotoxicity/a neurotoxicant...for example, antioxidants, nutraceuticals, etc.,..?
Chapter 5 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 5 - Prob. 1QCh. 5 - Prob. 2QCh. 5 - Prob. 3QCh. 5 - Prob. 4QCh. 5 - Prob. 5QCh. 5 - Prob. 6QCh. 5 - Prob. 7QCh. 5 - Prob. 8QCh. 5 - Prob. 9QCh. 5 - Prob. 10Q
Ch. 5 - Prob. 11QCh. 5 - Prob. 12QCh. 5 - Prob. 1RQCh. 5 - Prob. 2RQCh. 5 - Prob. 3RQCh. 5 - Prob. 4RQCh. 5 - Prob. 5RQCh. 5 - Prob. 6RQCh. 5 - Prob. 7RQCh. 5 - Prob. 8RQCh. 5 - Prob. 9RQCh. 5 - Prob. 10RQCh. 5 - Prob. 11RQCh. 5 - Prob. 12RQCh. 5 - Prob. 13RQCh. 5 - Prob. 14RQCh. 5 - Prob. 15RQCh. 5 - Prob. 16RQCh. 5 - Prob. 17RQCh. 5 - Prob. 18RQCh. 5 - Prob. 19RQCh. 5 - Prob. 20RQCh. 5 - Prob. 21RQCh. 5 - Prob. 22RQCh. 5 - Prob. 23RQCh. 5 - Prob. 24RQCh. 5 - Prob. 25RQCh. 5 - Prob. 26RQCh. 5 - Prob. 27RQCh. 5 - Prob. 28RQCh. 5 - Prob. 29RQCh. 5 - Prob. 30RQCh. 5 - Prob. 31RQCh. 5 - Prob. 32FBCh. 5 - Prob. 33FBCh. 5 - Prob. 34FBCh. 5 - Prob. 35FBCh. 5 - Prob. 36FBCh. 5 - Prob. 37FBCh. 5 - Prob. 38FBCh. 5 - Prob. 39FBCh. 5 - Prob. 40FBCh. 5 - Prob. 41FBCh. 5 - Prob. 42SACh. 5 - Prob. 43SACh. 5 - Prob. 44SACh. 5 - Prob. 45SACh. 5 - Prob. 46SACh. 5 - Prob. 47TQCh. 5 - Prob. 48TQCh. 5 - Prob. 49TQCh. 5 - Prob. 50TQCh. 5 - Prob. 51TQCh. 5 - Prob. 52TQCh. 5 - Prob. 53TQCh. 5 - Prob. 54TQCh. 5 - Prob. 55TQCh. 5 - Prob. 56TQCh. 5 - Prob. 57TQCh. 5 - Prob. 58TQCh. 5 - Prob. 59TQCh. 5 - Prob. 60TQCh. 5 - Prob. 61TQCh. 5 - Prob. 62TQCh. 5 - Prob. 63TQCh. 5 - Prob. 64TQCh. 5 - Prob. 65TQCh. 5 - Prob. 66TQCh. 5 - Prob. 67TQCh. 5 - Prob. 68TQCh. 5 - Prob. 69TQCh. 5 - Prob. 70TQ
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Imagine that aldolase can react with the seven carbon molecule Sedoheptulose-1,7-bisphosphate (below). Use the mechanism to predict the two products generated. Please draw out the stereochemistry in a fischer projection.arrow_forwardSodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition? Please draw out the mechanism and show how it inhibits this.arrow_forwardShow the fate of the proton on the 4-Oxygen molecule of F-1,6-BP. Please include a drawing showing the electron flow that occurs.arrow_forward
- 1. Which one is the major organic product obtained from the following aldol condensation? O NaOH, H₂O heat A B C D Earrow_forwardAn organic chemist ordered the wrong item. She wanted to obtain 1-hydroxy-2-butanone, butinstead ordered 2-hydroxybutyraldehyde. As a good biochemist, show how the organic chemistcould use biological catalysis to make her desired compound. Please show the mechanism by drawing.arrow_forwardShow the fate of the hydrogen on carbon-2 of glucose. Please draw out the structure using curve arrows to show electron flow.arrow_forward
- 3. Which one of the compounds below is the major product formed by the reaction sequence shown here? CH3 + CH3NO2 NaOH H2, Ni ? nitromethane acetophenone OH OH HO HN- u x x x x Ph A HO -NH2 HO H Ph Ph Ph N- H B Ph NH2 D Earrow_forward4. Only ONE of the five compounds below can be prepared by an aldol condensation in which a single carbonyl compound is treated with base. Which one is it? To solve this problem, reverse the aldol condensation that formed each of these molecules to find out what two molecules came together to make the products. The one in which the two molecules are identical is the answer. Ph Ph ཚིག གནས ག ནཱ ཀ ན ཀནཱ A Ph H B Ph Ph H D Ph. Ph Ph E Harrow_forward5. Which one is the major organic product obtained from the following reaction sequence? First, equimolar amounts of cyclopentanone and LDA are mixed at -78°C. Then propionaldehyde (propanal) is added. Addition of aqueous acid completes the process. LDA, -78°C. 1. 2. H₂O* H A B H 0 D H H Earrow_forward
- 2. Which one is the major organic product obtained from the following reaction? NaOH, H₂O heat A B C D Earrow_forwardCH3CH2CHO + propanal PhCH2CHO 2-phenylacetaldehyde mixture of four products NaOH 10. In the crossed aldol reaction of propanal and 2-phenylacetaldehyde shown above, a mixture of four products will be formed. Which ONE of the compounds below will NOT be formed in this crossed aldol reaction? OH Ph A H OH OH Ph H B OH OH H H H Ph Ph C Ph D Earrow_forwardAn organic chemist ordered the wrong item. She wanted to obtain 1-hydroxy-2-butanone, butinstead ordered 2-hydroxybutyraldehyde. As a good biochemist, show how the organic chemistcould use biological catalysis to make her desired compound.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Principles Of Radiographic Imaging: An Art And A ...Health & NutritionISBN:9781337711067Author:Richard R. Carlton, Arlene M. Adler, Vesna BalacPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning- Case Studies In Health Information ManagementBiologyISBN:9781337676908Author:SCHNERINGPublisher:Cengage
Medical Terminology for Health Professions, Spira...Health & NutritionISBN:9781305634350Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. SchroederPublisher:Cengage Learning
Principles Of Radiographic Imaging: An Art And A ...
Health & Nutrition
ISBN:9781337711067
Author:Richard R. Carlton, Arlene M. Adler, Vesna Balac
Publisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Case Studies In Health Information Management
Biology
ISBN:9781337676908
Author:SCHNERING
Publisher:Cengage
Medical Terminology for Health Professions, Spira...
Health & Nutrition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Cengage Learning