Chapter 5, Problem 50TQ

Summary Introduction

To review:

The common features of the following amino acids: serine (Ser), glutamic acid (Glu), lysine (Lys), and glutamine (Gln). Also, the reason for the disruption in folding of IUPs due to these amino acids.

Introduction:

Intrinsically unstructured proteins (IUPs) are certain partially or fully unfolded proteins that lack a native structure. Most of such proteins are present in eukaryotes (45%) whereas only 2 to 4% are found in prokaryotes. They can perform a diversity of functions such as signal transduction, transcription, translation, cell proliferation as well as assembly of the multiprotein complex.