Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 41, Problem 4RQ
When a dehydrated human patient needs to be given fluids intravenously, he or she is given:
- water, which is hypotonic with respect to body fluids
- saline at a concentration that is isotonic with respect to body fluids
- glucose because it is a non-electrolyte
- blood
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 41 Solutions
Biology 2e
Ch. 41 - Figure 41.5 Which of the following statements...Ch. 41 - Figure 41.6 Which of the following statements...Ch. 41 - Figure 41.8 Loop diuretics are drugs sometimes...Ch. 41 - When a dehydrated human patient needs to be given...Ch. 41 - The sodium ion is at the highest concentration in:...Ch. 41 - Cells in a hypertonic solution tend to: shrink due...Ch. 41 - The macula densa is/are: present in the renal...Ch. 41 - The osmolarity of body fluids is maintained at...Ch. 41 - The gland located at the top of the kidney is the...Ch. 41 - Active transport of K+ in Malpighian tubules...
Ch. 41 - Contractile vacuoles in microorganisms:...Ch. 41 - Flame cells are primitive excretory organs found...Ch. 41 - BUN is. blood urea nitrogen blood uric acid...Ch. 41 - Human beings accumulate ____before____ excreting...Ch. 41 - Renin is made by. granular cells of the...Ch. 41 - Patients with Addison's disease retain water...Ch. 41 - Which hormone elicits the 'fight or flight”...Ch. 41 - Why is excretion important in order to achieve...Ch. 41 - Why do electrolyte ions move across membranes by...Ch. 41 - Why are the loop of Henle and vasa recta important...Ch. 41 - Describe the structure of the kidney.Ch. 41 - Why might specialized organs have evolved for...Ch. 41 - Explain two different excretory systems other than...Ch. 41 - In terms of evolution, why might the urea cycle...Ch. 41 - Compare and contrast the formation of urea and...Ch. 41 - Describe how hormones regulate blood pressure,...Ch. 41 - How does the renin-angiotensin-aldosterone...
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