Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Question
Chapter 4, Problem 9P
Summary Introduction
To analyze:
The ABO, Rhesus (Rh) and MN blood group systems.
Determination of the following aspects from the given information:
a. The genotypes for a child with a blood group – A, Rh-, M
Woman – O, Rh-, MN
Man – A, Rh+, M.
b. The proportion of children born to a man with genotype IAIB Rr MN and woman with IAi Rr NN will have blood types B Rh- MN.
c. Paternity of a child having blood group O Rh- MN with a man having blood group B Rh+ N, a woman with A Rh+ MN.
Introduction:
A) ABO blood group system- The human blood group system is classified using antigens present on the RBC's (Red blood cells or erythrocyte). ABO blood types were revealed by the Austrian physician Karl Landsteiner (1901). ABO blood group is characterized under multiple alleles that show three or more alternative forms of a gene present on the same locus.
B) Rh blood group system:
Rhesus factor or Rhesus antigen is another isoantigen of RBC. It is the second most blood group system after ABO blood group system. The “Rh” factor is first described in Rhesus monkeys. The expression of Rh factors is denoted in Rh+ - expressed (antigen present), Rh- - deletion of the protein leads to the suppression of antigen (absence of antigen). The Rh factor is crucial during transfusion of blood from a donor to a recipient.
If the donor's Rh factor does not match with that of the recipient, it will lead to a transfusion reaction that causes hemolytic anemia. During pregnancy, Rh factor testing is very essential.
- Rh + can accept the donation of either Rh+ or Rh-.
- Rh- can only accept Rh- blood, or it will agglutinate.
C) MN blood group system-
MN blood group is discovered by Landsteiner and Levine. The MN Blood groups genes are closely linked genes present on chromosome 4. The alleles M and N show co-dominance that can have both
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What would the offspring's blood type be if the mother is type O+ (she is homozygous for Rh factor) and the father is A- (he is homozygous for type A)? Hint: You have to do two Punnett squares. The two Punnett squares must be shown to get the full points. After doing the Punnett squares, write down the possibilities of the offspring’s blood type.
A woman who has blood type A positive has a daughter who is type O positive and a son who is type B negative. Rh positive is a trait that shows simple dominance over Rh negative and is designated by the alleles R and r, respectively. A third gene for the MN blood group has codominant alleles M and N.
If both children are of blood type M in addition to their ABO blood type, list all of the possible parental phenotypes for the ABO, MN and Rh traits.
Several genes in humans in addition to the ABO gene () give rise to recognizable antigens on the surface of the red blood cells. The
Rh marker is determined by positive (R) and negative alleles () of gene R, where R is completely dominant to r. The presence of M and
N surface proteins are controlled by two codominant alleles of gene L (LM and LM. For each mother-child pair, choose the father of
the child from among the males in the right column. (Assume that all mothers and fathers are HH; there is no involvement of the
Bombay phenotype.)
Paternal genotypes maybe used once, more than once, or not at all. Each mother-child pair matches with one or more than one
paternal genotype.
Maternal phenotype:
Child phenotype:
Paternal genotype:
Reset
A, M, Rh(neg)
O, M, Rh(pos)
B, N, Rh(neg)
O, N, Rh(pos)
O, M, Rh(neg)
A, MN, Rh(pos)
A, N, Rh(pos)
AB, MN, Rh(pos)
B, N, Rh(pos)
A, MN, Rh(neg)
Genotypes of
possible fathers
AiLMLN rr
BiLMLN RR
ii LNLN rr
ii LMLM rr
AALMLN RR
Chapter 4 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 4 - 1. Define and distinguish incomplete penetrance...Ch. 4 -
2. Define and distinguish epistasis and...Ch. 4 - When working on barley plants, two researchers...Ch. 4 - Fifteen bacterial colonies growing on a complete...Ch. 4 - 5. In a type of parakeet known as a “budgie,”...Ch. 4 - 6. The and blood groups are given below for four...Ch. 4 - The wild-type color of horned beetles is black,...Ch. 4 - 8. Two genes interact to produce various...Ch. 4 - Prob. 9PCh. 4 - 10. In rats, gene produces black coat color if the...
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