Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 4, Problem 19QP
Analysis of X-Linked Dominant and Recessive Traits
Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The
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Suppose a man carries a very uncommon dominant mutation for a deadly muscular disease that doesn't show up until people are usually over 50 years of age (he has the disease). He and his wife are expecting their first child--a girl. What is the probability she will also have the disease if...
(1) it is autosomal(2) it is X-linked(3) it is Y-linked
Explain each answer in detail. Assume the penetrance of the trait is 100%.
Deletion mapping:
In your diploid model organism, one copy of the chromosome has all normal, dominant alleles of these genes. It is P
Q R STU V (not necessarily in that order). But the other copy of the chromosome has all recessive alleles, p q r
stu v. You find various deletions in which chunks of the "dominant chromosome" are missing, and so there are
recessive phenotypes as shown:
Phenotype -- recessive for genes...
T, Q, and U
R, V, and S
T and U
S and V
Q, P, and R
R and S
First deletion
Second deletion
Third deletion
Fourth deletion
Fifth deletion
Sixth deletion
Seventh deletion
T and Q
Figure out the order of the genes. Show some kind of work.
Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Usher’s Syndrome is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. One website (http://www.emedicine.com/oph/topic704.htm) says that Usher’s Syndrome Type II has been mapped to chromosome arm 1qe. Usher’s Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition
1) Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Within this pedigree, include Eric's parents, Eric himself, Eric's brother Dirk, and a daughter of Eric's. Be sure to follow all standard pedigree conventions.
2) Imagine you are a genetics counselor. Based upon the pattern of inheritance, what advice would you give Eric's…
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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- Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forwardAnalysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?arrow_forward
- Analysis of X-Linked Dominant and Recessive Traits In the eighteenth century, a young boy with a skin condition known as ichthyosis hystrix gravior was identified. The phenotype of this disorder includes thickening of skin and the formation of loose spines that are sloughed off periodically. This man married and had six sons, all of whom had the same condition. He also had several daughters, all of whom were unaffected. In all succeeding generations, the condition was passed on from father to son. What can you theorize about the location of the gene that causes ichthyosis hystrix gravior?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits The following is a pedigree for a common genetic trait. Analyze the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forwardPedigree 2: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B State the genotypes of individuals # 1 #4. C If individual #3 has another daughter with the same partner, what is the probability that this daughter will be affected (show the disease)?arrow_forward
- Nondisjunction which can affect sex chromosomes as well as autosomal chromosomes as a common cause of genetic disorders. Use the space provided to illustrate the process of nondisjunction with the end result being that one cell exhibits in the monopsony me while other one exhibits trisomy. Hint: a sperm will fertilize the egg and add it’s chromosome in the last step)arrow_forwardNeo-Mendelian Genetics: Complete dominance and overdominance Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Mary and Paul? If they plan to have four children, what is the probability that: all their children will be normal? ____________ they will have a son with Huntington’s disease? ___________ they will have a daughter inflicted with both conditions?____________arrow_forwardX-linked Recessive Inheritance A gene is described as X-linked when it occurs on the X chromosome and not the Y. Our convention is to indicate X-linkage by attaching the appropriate gene symbol as a superscript on the letter X. Commonly, the wild-type (+) allele is indicated with only a "+" to avoid having to type a superscript on a superscript. For example, a female that is heterozygous and carrying a recessive mutant allele is indicated as X+Xm. Note the convenience of the shorthand + for m+ in this situation. A mutant male has the genotype XmY. When working with X-linked inheritance, always include the X and Y chromosomes in the descriptions of genotypes, and include the sex (male or female) in the descriptions of the phenotypes (e.g., mutant male, wild-type female, etc.). Here are the genotypes and associated phenotypes for X-linked recessive inheritance: X+X+ Wild-type female X+Xm Wild-type female xmxm Mutant female X+Y xmy Wild-type male Mutant malearrow_forward
- Genetic Inheritance Patterms Retinitis pigmnentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Eric's form of RP is Usher's Syndrome, which is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. Usher's Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition. His brother, Dirk, does not have any symptoms of RP. Question below - short answer approach Imagine you are a genetics counselor, and Dirk, Erik's brother, comes in to see you. Based on his parents, what are Dirk's possible genotypes for RP? What advice would you give Dirk about the chances of Dirk's children having retinitis pigmentosa if his wife is not a carrier? How would your advice change if his wife fully has the disease? Describe all the possibilities,…arrow_forward17arrow_forwardComplete the following queatione BEFORE ATTEMPTING THE HW 1 BLACKBOARD ASSIGNMENT, In the following human pedigrees, the filled symbols represnent the affected individuals who suffer from the disease. Use A/a to represent alleles for autosomal traits and XIX/Ytorepresent alleles for X-linked traits. Use the uppercase letter to represent the dominant allele and the lowercase letterto represent the receasive allele. afected fomale Unafected female affected male Unaffected male Pedigree 1: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B. State the genotypes of individuals #1-#3. C. What is the probability that individual #4 is a carrier of this disease if his mother is homozygous dominant and his father is heterozygous? Pedigree 2: What is the most likely mode of inhentance of this disease? Choose from: autosomal dominant, autosomal recessive X-linked dominant X-linked recessive.…arrow_forward
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