Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 39.6, Problem 1MI
What cells and tissues make up the pseudomembrane?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 39 Solutions
Prescott's Microbiology
Ch. 39.1 - What organisms serve as the environmental...Ch. 39.1 - How is the M protein also thought to be involved...Ch. 39.1 - Prob. 3MICh. 39.1 - Why do you think chlamydiae differentiate into...Ch. 39.1 - Compare and contrast the means by which people...Ch. 39.1 - Prob. 1.3RIACh. 39.1 - What are the three major causes of meningitis? Why...Ch. 39.1 - Prob. 2.2RIACh. 39.1 - What is the reason for the complex antibiotic...Ch. 39.1 - How do multidrug-resistant strains of tuberculosis...
Ch. 39.1 - Prob. 3.1RIACh. 39.1 - What is the mechanism by which PTx kills host...Ch. 39.1 - Prob. 3.3RIACh. 39.1 - Describe the streptococcal exotoxins and how they...Ch. 39.1 - Prob. 4.2RIACh. 39.2 - What are the three stages of Lyme disease? What...Ch. 39.2 - Prob. 1RIACh. 39.2 - Prob. 2RIACh. 39.2 - Prob. 3RIACh. 39.2 - Prob. 4RIACh. 39.2 - How does transovarian passage occur?Ch. 39.3 - What are the chief differences between tuberculoid...Ch. 39.3 - How does H. pylori increase the local pH in its...Ch. 39.3 - Prob. 3MICh. 39.3 - Prob. 4MICh. 39.3 - Prob. 5MICh. 39.3 - Prob. 1.1RIACh. 39.3 - Why do you think the slow growth rate of M. leprae...Ch. 39.3 - Prob. 2.1RIACh. 39.3 - Prob. 2.2RIACh. 39.3 - Prob. 2.3RIACh. 39.3 - Prob. 2.4RIACh. 39.3 - Prob. 2.5RIACh. 39.3 - Prob. 3.1RIACh. 39.3 - Prob. 3.2RIACh. 39.3 - What is the difference between S. aureus and MRSA?Ch. 39.3 - Prob. 3.4RIACh. 39.3 - Prob. 3.5RIACh. 39.3 - Prob. 3.6RIACh. 39.4 - How do the neurological effects of botulinum toxin...Ch. 39.4 - To which E. coli class does the strain 0157:H7...Ch. 39.4 - How can Clostridium botulinum cause disease even...Ch. 39.4 - Compare the gastroenteritis caused by Vibrio...Ch. 39.4 - Prob. 2.1RIACh. 39.4 - Compare toxigenic E. coli disease with invasive...Ch. 39.4 - Prob. 2.3RIACh. 39.4 - Prob. 3.1RIACh. 39.4 - Prob. 3.2RIACh. 39.4 - Prob. 3.3RIACh. 39.5 - Prob. 1MICh. 39.5 - Prob. 1RIACh. 39.5 - Prob. 2RIACh. 39.5 - How is ornithosis transmitted?Ch. 39.5 - Prob. 4RIACh. 39.6 - What cells and tissues make up the pseudomembrane?Ch. 39.6 - Prob. 2MICh. 39.6 - Prob. 1RIACh. 39.6 - In both C. difficileassociated disease and...Ch. 39.6 - Prob. 3RIACh. 39 - Describe a typhoid carrier. How does one become a...Ch. 39 - Many consider cholera as the most severe form of...Ch. 39 - Compare the three stages of syphilis and Lyme...Ch. 39 - While many Vibrio cholerae strains are found in...Ch. 39 - The spirochete Borrelia burgdorferi causes Lyme...
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