Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 3, Problem 2CS
If you were in Thomas’s position, would you want to be tested and possibly learn that you were almost certain to develop the disorder sometime in the next 5–10 years?
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The father of three sons and two daughters begins to show symptoms of Huntington's disease. What is the probability that Sam, the man’s second oldest son (II-2), will suffer from the disease if he lives a normal life span? Sam’s mother and her ancestors do not have the disease. Sam's father was adopted, so we do not know his biological family history for Huntington disease. Explore all possible outcomes for Sam and explain your reasoning. What about the risk to Sam's sisters? Would that be the same or not?
The father of five children begins to show symptoms of huntington disease. what is the probability that same, the man's second oldest son (11-2),, will suffer from the disease if he lives a normal life span? Sam's mother and her ancestors do not have the diseas. Sam's father was adopted, so we do not know his biological family history for hunutington disease. Explore all possible outcome for sam and explain your reasoning
Below you may find the pedigree diagram for a family with two boys having childhood onset epileptic encephalopathy. Please indicate 4 different inheritance models and state your reasons briefly for this disorder by considering the pedigree.
Chapter 3 Solutions
Concepts of Genetics (12th Edition)
Ch. 3 - Pigeons may exhibit a checkered or plain color...Ch. 3 - Considering the Mendelian traits round versus...Ch. 3 - Using the forked-line, or branch diagram, method,...Ch. 3 - In one of Mendels dihybrid crosses, he observed...Ch. 3 - The following pedigree is for myopia...Ch. 3 - If they seek genetic counseling, what issues would...Ch. 3 - If you were in Thomass position, would you want to...Ch. 3 - If Thomas tests positive for the HD allele, should...Ch. 3 - HOW DO WE KNOW? In this chapter, we focused on the...Ch. 3 - CONCEPT QUESTION Review the Chapter Concepts list...
Ch. 3 - Albinism in humans is inherited as a simple...Ch. 3 - Which of Mendels postulates are illustrated by the...Ch. 3 - Discuss how Mendels monohybrid results served as...Ch. 3 - What advantages were provided by Mendels choice of...Ch. 3 - Mendel crossed peas having round seeds and yellow...Ch. 3 - Based on the preceding cross, what is the...Ch. 3 - Which of Mendels postulates can only be...Ch. 3 - In a cross between a black and a white guinea pig,...Ch. 3 - What is the basis for homology among chromosomes?Ch. 3 - In Drosophila, gray body color is dominant to...Ch. 3 - How many different types of gametes can be formed...Ch. 3 - Mendel crossed peas having green seeds with peas...Ch. 3 - In a study of black guinea pigs and white guinea...Ch. 3 - Mendel crossed peas having round green seeds with...Ch. 3 - Prob. 17PDQCh. 3 - The following are F2 results of two of Mendels...Ch. 3 - In assessing data that fell into two phenotypic...Ch. 3 - Prob. 20PDQCh. 3 - Consider the following pedigree. Predict the mode...Ch. 3 - Draw all possible conclusions concerning the mode...Ch. 3 - For decades scientists have been perplexed by...Ch. 3 - A wrongful birth case was recently brought before...Ch. 3 - TaySachs disease (TSD) is an inborn error of...Ch. 3 - Datura stramonium (the Jimsonweed) expresses...Ch. 3 - The wild-type (normal) fruit fly, Drosophila...Ch. 3 - To assess Mendels law of segregation using...Ch. 3 - Albinism, caused by a mutational disruption in...Ch. 3 - (a) Assuming that Migaloos albinism is caused by a...
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- If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?arrow_forwardHuntington's disease is an autosomal dominant disorder caused by a gradual build up of a misfolded protein in the brain. a 45 year old man finds out that he has Huntington's which his father died from but he knows his mother never developed the disease and lived to be 90. He is married with one daughter and his wife doesn't have the disease. What are the chances that his daughter develop Huntington? 25%, 50%, 75%, 100% or cannot tell from the informationarrow_forwardCystic fibrosis (CF) is an autosomal recessive trait (a). Assume that Emily (who has CF) decides to have children with a man who does not have CF and who is not a carrier of CF. What are their genotypes, and what is the probability that they will have a child who is a carrier for CF?arrow_forward
- If a mother and father have a son who has a dominant disease like Marfan syndrome, but they both do NOT (they are healthy), would would the Punnett square look like for the parents? What can we conclude about the health of their son from this?arrow_forwardExamine the autoradiogram below. Three loci of VNTRS from a mother (M), child (C) and three potential fathers (F1, F2, F3) of the child are shown. From your analysis of this data, are any of these men potentially the father of the child or not? If so, which one? Explain your answer.arrow_forwardHuntington's Chorea is an autosomal dominant trait. Below is a pedigree of a family with Huntington's disease. If III-6 had a child with a healthy individual, what would be the chance they would have a child with Huntington's? Group of answer choices a 100% b 25% c 50% d 0%arrow_forward
- Huntington disease (HD) is a genetic disorder that usually first appears in middle age and, over time, leads to involuntary movements, impaired speech, difficulty swallowing and speaking, and cognitive decline. There is no cure for HD, and affected individuals eventually die, usually after 10 to 15 years of progressively worsening symptoms. Huntington disease is inherited as an autosomal dominant disorder. Presymptomatic genetic testing for HD is available for people with a family history of the disease. Individuals who have a parent with HD have a 50% chance of inheriting the HD gene and eventually having HD. Some of these individuals want to know if they will eventually get the disease, and they undergo presymptomatic genetic testing. Others do not want to know, given that there is no cure or effective treatment for the disease. If you were at risk for HD, would you want to undergo genetic testing? What are some reasons for and against having a genetic test for HD?arrow_forwardDefine and explain the term "non-concordance." Why is this such an important concept to understand.arrow_forwardI'm having trouble finding the dependent and independent variables of this scenaro: Average IQ scores for young school children are known to be 100 (SD = 15). However, the literature indicates that children’s intelligence may be decreased if their mothers have German measles during pregnancy. Using hospital records, a researcher obtained a sample of n = 25 school children whose mothers all had German measles during their pregnancies. Do the data indicate that children born to mothers who had German measles during the pregnancy have significantly lower IQ scores than typical young school children?arrow_forward
- A couple has had a child born with neurofibromatosis. They come to your genetic counseling office for help. After taking an extensive family history, you determine that there is no history of this disease on either side of the family. The couple wants to have another child and wants to be advised about the risks of that child having neurofibromatosis. What advice do you give them?arrow_forwardA pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardThe figure below shows part of a family tree in which an inherited coagulopathy occurs. Analyze the case and evaluate the effects of the genes in the inheritance of characteristics. 2 3 6 7 9 10 8 KEY | Affected male Unaffected male Affected female OUnaffected female The gene causing the disease could be one of the following: Sex-linked recessive, sex-linked dominant, autosomal recessive, or autosomal dominant or whatever genetic terminology is suitable. Using diagrams, evaluate each of the four possibilities and then conclude which one fits the case study.arrow_forward
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